Extraneural infection route restricts prion conformational variability and attenuates the impact of quaternary structure on infectivity

Sheng Chun Chang; Maria Immaculata Arifin; Waqas Tahir; Keegan John McDonald; Doris Zeng; Hermann M. Schatzl; Samia Hannaoui; Sabine Gilch

doi:10.1371/journal.ppat.1012370

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Open Access

Peer-reviewed

Research Article

Extraneural infection route restricts prion conformational variability and attenuates the impact of quaternary structure on infectivity

Sheng Chun Chang,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Faculty of Veterinary Medicine, University of Calgary, Calgary, Canada
⨯
Maria Immaculata Arifin,

Roles Formal analysis, Investigation, Validation, Visualization, Writing – review & editing

Affiliation Faculty of Veterinary Medicine, University of Calgary, Calgary, Canada
⨯
Waqas Tahir,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Canadian and WOAH Reference Laboratory for BSE, Canadian Food Inspection Agency, Lethbridge, Canada
⨯
Keegan John McDonald,

Roles Investigation, Writing – review & editing

Affiliation Faculty of Veterinary Medicine, University of Calgary, Calgary, Canada
⨯
Doris Zeng,

Roles Investigation, Writing – review & editing

Affiliation Faculty of Veterinary Medicine, University of Calgary, Calgary, Canada
⨯
Hermann M. Schatzl,

Roles Formal analysis, Funding acquisition, Writing – review & editing

Affiliations Faculty of Veterinary Medicine, University of Calgary, Calgary, Canada, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Canada
⨯
Samia Hannaoui,

Roles Investigation, Supervision, Writing – review & editing

Affiliation Faculty of Veterinary Medicine, University of Calgary, Calgary, Canada
⨯
Sabine Gilch

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: sgilch@ucalgary.ca

Affiliations Faculty of Veterinary Medicine, University of Calgary, Calgary, Canada, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Canada

https://orcid.org/0000-0001-5923-3464

⨯

Extraneural infection route restricts prion conformational variability and attenuates the impact of quaternary structure on infectivity

Sheng Chun Chang,
Maria Immaculata Arifin,
Waqas Tahir,
Keegan John McDonald,
Doris Zeng,
Hermann M. Schatzl,
Samia Hannaoui,
Sabine Gilch

Published: July 8, 2024
https://doi.org/10.1371/journal.ppat.1012370

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