The nuclear localization signal of CPSF6 governs post-nuclear import steps of HIV-1 infection

Nicholas Rohlfes; Rajalingam Radhakrishnan; Parmit K. Singh; Gregory J. Bedwell; Alan N. Engelman; Adarsh Dharan; Edward M. Campbell

doi:10.1371/journal.ppat.1012354

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Open Access

Peer-reviewed

Research Article

The nuclear localization signal of CPSF6 governs post-nuclear import steps of HIV-1 infection

Nicholas Rohlfes,

Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Integrative Cell Biology Graduate Program, Loyola University Chicago, Maywood, Illinois, United States of America
⨯
Rajalingam Radhakrishnan,

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Parmit K. Singh,

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliations Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Gregory J. Bedwell,

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliations Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Alan N. Engelman,

Roles Funding acquisition, Writing – review & editing

Affiliations Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Adarsh Dharan ,

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Supervision, Writing – review & editing

* E-mail: adharan@iu.edu (AD); ecampbell@luc.edu (EMC)

Affiliation Department of Biology, Indiana University, Bloomington, Indiana, United States of America
⨯
Edward M. Campbell

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

* E-mail: adharan@iu.edu (AD); ecampbell@luc.edu (EMC)

Affiliations Integrative Cell Biology Graduate Program, Loyola University Chicago, Maywood, Illinois, United States of America, Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois, United States of America

https://orcid.org/0000-0001-5665-9195

⨯

The nuclear localization signal of CPSF6 governs post-nuclear import steps of HIV-1 infection

Nicholas Rohlfes,
Rajalingam Radhakrishnan,
Parmit K. Singh,
Gregory J. Bedwell,
Alan N. Engelman,
Adarsh Dharan,
Edward M. Campbell

Published: January 17, 2025
https://doi.org/10.1371/journal.ppat.1012354

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