IL-10 suppresses T cell expansion while promoting tissue-resident memory cell formation during SARS-CoV-2 infection in rhesus macaques

• Christine E. Nelson,

  Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliation T lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

  https://orcid.org/0000-0003-3879-9105

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• Taylor W. Foreman,

  Roles Investigation, Writing – review & editing

  Current address: Early Oncology R&D, AstraZeneca, Gaithersburg, Maryland, United States of America

  Affiliation T lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

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• Eduardo R. Fukutani,

  Roles Formal analysis, Writing – review & editing

  Affiliation Laboratório de Pesquisa Clínica e Translacional, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil

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• Keith D. Kauffman,

  Roles Writing – review & editing

  Affiliation T lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

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• Shunsuke Sakai,

  Roles Investigation, Writing – review & editing

  Affiliation T lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

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• Joel D. Fleegle,

  Roles Formal analysis, Writing – review & editing

  Affiliation Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

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• Felipe Gomez,

  Roles Formal analysis, Writing – review & editing

  Affiliation Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

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• NIAID/DIR Tuberculosis Imaging Program ,

  ¶Membership of NIAID/DIR Tuberculosis Imaging Program is listed in the Acknowledgments.

  Affiliation Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

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• Sydnee T. Gould,

  Roles Formal analysis, Writing – review & editing

  Current address: Molecular and Cell Biology, Division of Immunology and Molecular Medicine, University of California, Berkeley, California, United States of America

  Affiliation T lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

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• Cyril Le Nouën,

  Roles Investigation, Writing – review & editing

  Affiliation RNA Viruses Section, Laboratory of Infectious Disease, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

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• Xueqiao Liu,

  Roles Investigation, Writing – review & editing

  Affiliation RNA Viruses Section, Laboratory of Infectious Disease, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

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• Tracey L. Burdette,

  Roles Investigation, Writing – review & editing

  Affiliation SARS-CoV-2 Virology Core, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Nicole L. Garza,

  Roles Investigation, Writing – review & editing

  Affiliation SARS-CoV-2 Virology Core, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Bernard A. P. Lafont,

  Roles Investigation, Writing – review & editing

  Affiliation SARS-CoV-2 Virology Core, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Kelsie Brooks,

  Roles Investigation, Writing – review & editing

  Affiliation Barrier Immunity Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

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• Cecilia S. Lindestam Arlehamn,

  Roles Resources, Writing – review & editing

  Affiliation Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, California, United States of America

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• Daniela Weiskopf,

  Roles Resources, Writing – review & editing

  Affiliation Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, California, United States of America

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• Alessandro Sette,

  Roles Resources, Writing – review & editing

  Affiliations Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, California, United States of America, Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, California, United States of America

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• Heather D. Hickman,

  Roles Resources, Writing – review & editing

  Affiliation Viral Immunity and Pathogenesis Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

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• Ursula J. Buchholz,

  Roles Supervision, Writing – review & editing

  Affiliation RNA Viruses Section, Laboratory of Infectious Disease, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

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• Reed F. Johnson,

  Roles Investigation, Supervision, Writing – review & editing

  Affiliation SARS-CoV-2 Virology Core, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

  ⨯
• Jason M. Brenchley,

  Roles Supervision, Writing – review & editing

  Affiliation Barrier Immunity Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

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• James P. Oberman,

  Roles Resources, Writing – review & editing

  Affiliation Holy Cross Germantown Hospital, Affiliate of National Breathe Free Sinus and ENT Center, Frederick Breathe Free Sinus and ENT Center, Frederick, Maryland, United States of America

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• Artur T. L. Quieroz,

  Roles Formal analysis, Writing – review & editing

  Affiliation Laboratório de Pesquisa Clínica e Translacional, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil

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• Bruno B. Andrade,

  Roles Formal analysis, Writing – review & editing

  Affiliation Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

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• Laura E. Via,

  Roles Formal analysis, Supervision, Writing – review & editing

  Affiliations Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America, Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America, Institute of Infectious Disease & Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Observatory, South Africa

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•  [ ... ],
• Daniel L. Barber

  Roles Conceptualization, Formal analysis, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: barberd@niaid.nih.gov

  Affiliation T lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

  https://orcid.org/0000-0001-7008-7509

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