SARS-CoV-2 spike-induced syncytia are senescent and contribute to exacerbated heart failure

• Huilong Li ,

  Contributed equally to this work with: Huilong Li, Luming Wan, Muyi Liu, Enhao Ma, Linfei Huang, Yilong Yang, Qihong Li

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Software, Validation, Visualization, Writing – original draft

  Affiliations Beijing Institute of Biotechnology, Beijing, China, College of Basic Medical Sciences, School of Medicine, Zhejiang University, Hangzhou, China

  ⨯
• Luming Wan ,

  Contributed equally to this work with: Huilong Li, Luming Wan, Muyi Liu, Enhao Ma, Linfei Huang, Yilong Yang, Qihong Li

  Roles Conceptualization, Funding acquisition

  Affiliation Beijing Institute of Biotechnology, Beijing, China

  ⨯
• Muyi Liu ,

  Contributed equally to this work with: Huilong Li, Luming Wan, Muyi Liu, Enhao Ma, Linfei Huang, Yilong Yang, Qihong Li

  Roles Data curation

  Affiliation Beijing Institute of Biotechnology, Beijing, China

  ⨯
• Enhao Ma ,

  Contributed equally to this work with: Huilong Li, Luming Wan, Muyi Liu, Enhao Ma, Linfei Huang, Yilong Yang, Qihong Li

  Roles Data curation

  Affiliation Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University, Beijing, China

  ⨯
• Linfei Huang ,

  Contributed equally to this work with: Huilong Li, Luming Wan, Muyi Liu, Enhao Ma, Linfei Huang, Yilong Yang, Qihong Li

  Roles Formal analysis

  Affiliation Beijing Institute of Biotechnology, Beijing, China

  ⨯
• Yilong Yang ,

  Contributed equally to this work with: Huilong Li, Luming Wan, Muyi Liu, Enhao Ma, Linfei Huang, Yilong Yang, Qihong Li

  Roles Methodology

  Affiliation Beijing Institute of Biotechnology, Beijing, China

  ⨯
• Qihong Li ,

  Contributed equally to this work with: Huilong Li, Luming Wan, Muyi Liu, Enhao Ma, Linfei Huang, Yilong Yang, Qihong Li

  Roles Resources

  Affiliation The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China

  ⨯
• Yi Fang,

  Roles Validation

  Affiliation The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China

  ⨯
• Jingfei Li,

  Roles Data curation

  Affiliation Beijing Institute of Biotechnology, Beijing, China

  ⨯
• Bingqing Han,

  Roles Validation

  Affiliation Beijing Institute of Biotechnology, Beijing, China

  ⨯
• Chang Zhang,

  Roles Data curation

  Affiliation Beijing Institute of Biotechnology, Beijing, China

  ⨯
• Lijuan Sun,

  Roles Validation

  Affiliation Beijing Yaogen Biotechnology Co.Ltd, Beijing, China

  ⨯
• Xufeng Hou,

  Roles Validation

  Affiliation Beijing Yaogen Biotechnology Co.Ltd, Beijing, China

  ⨯
• Haiyang Li,

  Roles Supervision

  Affiliation Beijing Anzhen Hospital, Capital Medical University, Beijing, China

  ⨯
• Mingyu Sun,

  Roles Methodology

  Affiliation Beijing Anzhen Hospital, Capital Medical University, Beijing, China

  ⨯
• Sichong Qian,

  Roles Methodology

  Affiliation Beijing Anzhen Hospital, Capital Medical University, Beijing, China

  ⨯
• Xuejing Duan,

  Roles Methodology

  Affiliation Department of Pathology, Fuwai Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China

  ⨯
• Ruzhou Zhao,

  Roles Formal analysis

  Affiliation Beijing Institute of Biotechnology, Beijing, China

  ⨯
• Xiaopan Yang,

  Roles Formal analysis

  Affiliation Beijing Institute of Biotechnology, Beijing, China

  ⨯
• Yi Chen,

  Roles Methodology

  Affiliation Beijing Institute of Biotechnology, Beijing, China

  ⨯
• Shipo Wu,

  Roles Software

  Affiliation Beijing Institute of Biotechnology, Beijing, China

  ⨯
• Xuhui Zhang,

  Roles Software

  Affiliation Beijing Yaogen Biotechnology Co.Ltd, Beijing, China

  ⨯
• Yanhong Zhang,

  Roles Investigation

  Affiliation Beijing Institute of Biotechnology, Beijing, China

  ⨯
• Gong Cheng,

  Roles Resources

  Affiliation Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University, Beijing, China

  ⨯
• Gengye Chen ,

  Roles Validation

  ¶‡ These authors jointly supervised the work.

  Affiliation People’s Hospital of Ningxia Hui Autonomous Region, Yinchuan, China

  ⨯
• Qi Gao ,

  Roles Resources

  ¶‡ These authors jointly supervised the work.

  Affiliation Beijing Yaogen Biotechnology Co.Ltd, Beijing, China

  ⨯
• Junjie Xu ,

  Roles Investigation

  ¶‡ These authors jointly supervised the work.

  Affiliation Beijing Institute of Biotechnology, Beijing, China

  ⨯
• Lihua Hou ,

  Roles Resources, Writing – review & editing

  ¶‡ These authors jointly supervised the work.

  Affiliations Beijing Institute of Biotechnology, Beijing, China, College of Basic Medical Sciences, School of Medicine, Zhejiang University, Hangzhou, China

  ⨯
• Congwen Wei ,

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Writing – original draft, Writing – review & editing

  ¶‡ These authors jointly supervised the work.

  Affiliation Beijing Institute of Biotechnology, Beijing, China

  ⨯
•  [ ... ],
• Hui Zhong

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Writing – original draft, Writing – review & editing

  * E-mail: towall@yahoo.com

  Affiliation Beijing Institute of Biotechnology, Beijing, China

  https://orcid.org/0000-0003-2128-9686

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