A genome-wide CRISPR/Cas9 knockout screen identifies TMEM239 as an important host factor in facilitating African swine fever virus entry into early endosomes

• Dongdong Shen ,

  Contributed equally to this work with: Dongdong Shen, Guigen Zhang, Xiaogang Weng

  Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing

  Affiliations State Key Laboratory for Animal Disease Control and Prevention, National African Swine Fever Para-reference Laboratory, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China, College of Veterinary Medicine, Northeast Agricultural University, Harbin, China

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• Guigen Zhang ,

  Contributed equally to this work with: Dongdong Shen, Guigen Zhang, Xiaogang Weng

  Roles Data curation, Investigation, Methodology

  Affiliation Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China

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• Xiaogang Weng ,

  Contributed equally to this work with: Dongdong Shen, Guigen Zhang, Xiaogang Weng

  Roles Data curation, Investigation, Methodology

  Affiliation Key Laboratory of Animal Cellular and Genetics Engineering of Heilongjiang Province, Engineering Research Center of Intelligent Breeding and Farming of Pig in Northern Cold Region, College of Life Science, Northeast Agricultural University, Harbin, China

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• Renqiang Liu,

  Roles Investigation

  Affiliation State Key Laboratory for Animal Disease Control and Prevention, National African Swine Fever Para-reference Laboratory, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China

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• Zhiheng Liu,

  Roles Methodology

  Affiliation Peking-Tsinghua Center for Life Sciences, School of Life Sciences, Peking University, Beijing, China

  ⨯
• Xiangpeng Sheng,

  Roles Methodology

  Affiliation State Key Laboratory for Animal Disease Control and Prevention, National African Swine Fever Para-reference Laboratory, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China

  ⨯
• Yuting Zhang,

  Roles Methodology

  Affiliation Key Laboratory of Animal Cellular and Genetics Engineering of Heilongjiang Province, Engineering Research Center of Intelligent Breeding and Farming of Pig in Northern Cold Region, College of Life Science, Northeast Agricultural University, Harbin, China

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• Yan Liu,

  Roles Methodology

  Affiliation Key Laboratory of Animal Cellular and Genetics Engineering of Heilongjiang Province, Engineering Research Center of Intelligent Breeding and Farming of Pig in Northern Cold Region, College of Life Science, Northeast Agricultural University, Harbin, China

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• Yanshuang Mu,

  Roles Methodology

  Affiliation Key Laboratory of Animal Cellular and Genetics Engineering of Heilongjiang Province, Engineering Research Center of Intelligent Breeding and Farming of Pig in Northern Cold Region, College of Life Science, Northeast Agricultural University, Harbin, China

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• Yuanmao Zhu,

  Roles Formal analysis

  Affiliation State Key Laboratory for Animal Disease Control and Prevention, National African Swine Fever Para-reference Laboratory, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China

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• Encheng Sun,

  Roles Formal analysis

  Affiliation State Key Laboratory for Animal Disease Control and Prevention, National African Swine Fever Para-reference Laboratory, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China

  ⨯
• Jiwen Zhang,

  Roles Formal analysis

  Affiliation State Key Laboratory for Animal Disease Control and Prevention, National African Swine Fever Para-reference Laboratory, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China

  ⨯
• Fang Li,

  Roles Formal analysis, Methodology

  Affiliation State Key Laboratory for Animal Disease Control and Prevention, National African Swine Fever Para-reference Laboratory, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China

  ⨯
• Changyou Xia,

  Roles Resources

  Affiliation State Key Laboratory for Animal Disease Control and Prevention, National African Swine Fever Para-reference Laboratory, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China

  ⨯
• Junwei Ge,

  Roles Methodology

  Affiliation College of Veterinary Medicine, Northeast Agricultural University, Harbin, China

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• Zhonghua Liu ,

  Roles Conceptualization, Resources, Validation

  * E-mail: liuzhonghua@neau.edu.cn (ZL); buzhigao@caas.cn (ZB); zhaodongming@caas.cn (DZ)

  Affiliation Key Laboratory of Animal Cellular and Genetics Engineering of Heilongjiang Province, Engineering Research Center of Intelligent Breeding and Farming of Pig in Northern Cold Region, College of Life Science, Northeast Agricultural University, Harbin, China

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• Zhigao Bu ,

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Validation, Writing – review & editing

  * E-mail: liuzhonghua@neau.edu.cn (ZL); buzhigao@caas.cn (ZB); zhaodongming@caas.cn (DZ)

  Affiliation State Key Laboratory for Animal Disease Control and Prevention, National African Swine Fever Para-reference Laboratory, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China

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•  [ ... ],
• Dongming Zhao

  Roles Conceptualization, Funding acquisition, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: liuzhonghua@neau.edu.cn (ZL); buzhigao@caas.cn (ZB); zhaodongming@caas.cn (DZ)

  Affiliation State Key Laboratory for Animal Disease Control and Prevention, National African Swine Fever Para-reference Laboratory, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China

  https://orcid.org/0000-0001-7161-6214

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