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Open Access
Peer-reviewed
Research Article
Cell-free assays reveal that the HIV-1 capsid protects reverse transcripts from cGAS immune sensing
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Tiana M. Scott ,
Contributed equally to this work with: Tiana M. Scott, Lydia M. Arnold
Roles Investigation, Methodology, Writing – review & editing
Affiliation Division of Microbiology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
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Lydia M. Arnold ,
Contributed equally to this work with: Tiana M. Scott, Lydia M. Arnold
Roles Investigation, Methodology, Writing – review & editing
Affiliation Division of Microbiology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
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Jordan A. Powers,
Roles Investigation, Writing – review & editing
Affiliation Division of Microbiology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
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Delaney A. McCann,
Roles Investigation, Writing – review & editing
Affiliation Division of Microbiology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
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Ana B. Rowe,
Roles Investigation, Writing – review & editing
Affiliation Division of Microbiology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
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Devin E. Christensen,
Roles Investigation, Methodology, Writing – review & editing
Affiliation Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
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Miguel J. Pereira,
Roles Methodology, Writing – review & editing
Affiliation Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
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Wen Zhou,
Roles Investigation, Methodology, Writing – review & editing
Affiliation Department of Immunology and Microbiology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China
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Rachel M. Torrez,
Roles Writing – review & editing
Affiliation Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
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Janet H. Iwasa,
Roles Writing – review & editing
Affiliation Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
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Philip J. Kranzusch,
Roles Funding acquisition, Methodology, Project administration, Supervision, Writing – review & editing
Affiliations Department of Microbiology, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
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Wesley I. Sundquist,
Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Writing – review & editing
Affiliation Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
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Jarrod S. Johnson
Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing
* E-mail: jarrod.johnson@path.utah.edu
Affiliation Division of Microbiology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
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Cell-free assays reveal that the HIV-1 capsid protects reverse transcripts from cGAS immune sensing
- Tiana M. Scott,
- Lydia M. Arnold,
- Jordan A. Powers,
- Delaney A. McCann,
- Ana B. Rowe,
- Devin E. Christensen,
- Miguel J. Pereira,
- Wen Zhou,
- Rachel M. Torrez,
- Janet H. Iwasa
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- Published: January 28, 2025
- https://doi.org/10.1371/journal.ppat.1012206