Intranasal respiratory syncytial virus vaccine attenuated by codon-pair deoptimization of seven open reading frames is genetically stable and elicits mucosal and systemic immunity and protection against challenge virus replication in hamsters

• Megan Levy ,

  Contributed equally to this work with: Megan Levy, Jessica W. Chen

  Roles Data curation, Formal analysis, Investigation, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

  Current address: School of Medicine, University of Washington, Seattle, Washington, United States of America

  Affiliation RNA Viruses Section, Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, Maryland, United States of America

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• Jessica W. Chen ,

  Contributed equally to this work with: Megan Levy, Jessica W. Chen

  Roles Data curation, Formal analysis, Investigation, Resources, Validation, Visualization, Writing – review & editing

  Current address: PhD Program in Virology, Division of Medical Sciences, Harvard Medical School, Boston, Massachussetts, United States of America

  Affiliation RNA Viruses Section, Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, Maryland, United States of America

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• Jaclyn A. Kaiser,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation RNA Viruses Section, Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, Maryland, United States of America

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• Hong-Su Park,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation RNA Viruses Section, Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, Maryland, United States of America

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• Xueqiao Liu,

  Roles Data curation, Formal analysis, Investigation, Writing – review & editing

  Affiliation RNA Viruses Section, Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, Maryland, United States of America

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• Lijuan Yang,

  Roles Investigation, Writing – review & editing

  Affiliation RNA Viruses Section, Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, Maryland, United States of America

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• Celia Santos,

  Roles Investigation, Writing – review & editing

  Affiliation RNA Viruses Section, Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, Maryland, United States of America

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• Ursula J. Buchholz,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Resources, Supervision, Visualization, Writing – review & editing

  Affiliation RNA Viruses Section, Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, Maryland, United States of America

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• Cyril Le Nouën

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: lenouenc@niaid.nih.gov

  Affiliation RNA Viruses Section, Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, Maryland, United States of America

  https://orcid.org/0000-0002-5719-4112

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