Type II and IV toxin-antitoxin systems coordinately stabilize the integrative and conjugative element of the ICESa2603 family conferring multiple drug resistance in Streptococcus suis

• Qibing Gu,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China, Key Lab of Animal Bacteriology, Ministry of Agriculture, Nanjing, China, OIE Reference Lab for Swine Streptococcosis, Nanjing, China

  ⨯
• Xiayu Zhu,

  Roles Conceptualization, Data curation, Methodology, Software

  Affiliations MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China, Key Lab of Animal Bacteriology, Ministry of Agriculture, Nanjing, China, OIE Reference Lab for Swine Streptococcosis, Nanjing, China

  ⨯
• Yong Yu,

  Roles Resources, Validation

  Affiliations MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China, Key Lab of Animal Bacteriology, Ministry of Agriculture, Nanjing, China, OIE Reference Lab for Swine Streptococcosis, Nanjing, China

  ⨯
• Tao Jiang,

  Roles Methodology, Visualization

  Affiliation Department of Stomatology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China

  ⨯
• Zihao Pan ,

  Roles Conceptualization, Formal analysis, Investigation, Project administration, Resources, Supervision, Validation, Writing – review & editing

  * E-mail: panzihao@njau.edu.cn (ZP); jialema@njau.edu.cn (JM); yaohch@njau.edu.cn (HY)

  Affiliations MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China, Key Lab of Animal Bacteriology, Ministry of Agriculture, Nanjing, China, OIE Reference Lab for Swine Streptococcosis, Nanjing, China

  ⨯
• Jiale Ma ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: panzihao@njau.edu.cn (ZP); jialema@njau.edu.cn (JM); yaohch@njau.edu.cn (HY)

  Affiliations MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China, Key Lab of Animal Bacteriology, Ministry of Agriculture, Nanjing, China, OIE Reference Lab for Swine Streptococcosis, Nanjing, China

  ⨯
• Huochun Yao

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: panzihao@njau.edu.cn (ZP); jialema@njau.edu.cn (JM); yaohch@njau.edu.cn (HY)

  Affiliations MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China, Key Lab of Animal Bacteriology, Ministry of Agriculture, Nanjing, China, OIE Reference Lab for Swine Streptococcosis, Nanjing, China

  https://orcid.org/0000-0002-3749-8557

  ⨯