Microglia and macrophages alterations in the CNS during acute SIV infection: A single-cell analysis in rhesus macaques

Xiaoke Xu; Meng Niu; Benjamin G. Lamberty; Katy Emanuel; Shawn Ramachandran; Andrew J. Trease; Mehnaz Tabassum; Jeffrey D. Lifson; Howard S. Fox

doi:10.1371/journal.ppat.1012168

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Open Access

Peer-reviewed

Research Article

Microglia and macrophages alterations in the CNS during acute SIV infection: A single-cell analysis in rhesus macaques

Xiaoke Xu,

Roles Formal analysis, Investigation, Methodology, Writing – original draft

Affiliation Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
⨯
Meng Niu,

Roles Data curation, Formal analysis, Methodology, Supervision, Writing – review & editing

Affiliation Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
⨯
Benjamin G. Lamberty,

Roles Investigation

Affiliation Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
⨯
Katy Emanuel,

Roles Investigation

Affiliation Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
⨯
Shawn Ramachandran,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
⨯
Andrew J. Trease,

Roles Formal analysis, Investigation

Affiliation Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
⨯
Mehnaz Tabassum,

Roles Investigation

Affiliation Department of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
⨯
Jeffrey D. Lifson,

Roles Investigation, Writing – review & editing

Affiliation AIDS and Cancer Virus Program, Frederick National Laboratory, Frederick, Maryland, United States of America
⨯
Howard S. Fox

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Project administration, Supervision, Writing – review & editing

* E-mail: hfox@unmc.edu

Affiliation Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

https://orcid.org/0000-0003-2032-374X

⨯

Microglia and macrophages alterations in the CNS during acute SIV infection: A single-cell analysis in rhesus macaques

Xiaoke Xu,
Meng Niu,
Benjamin G. Lamberty,
Katy Emanuel,
Shawn Ramachandran,
Andrew J. Trease,
Mehnaz Tabassum,
Jeffrey D. Lifson,
Howard S. Fox

Published: September 16, 2024
https://doi.org/10.1371/journal.ppat.1012168

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SIV
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Microglial cells
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Macrophages
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Bone marrow cells
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Homeostasis
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Central nervous system
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Inflammation
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