Deep mining of the Sequence Read Archive reveals major genetic innovations in coronaviruses and other nidoviruses of aquatic vertebrates

• Chris Lauber ,

  Contributed equally to this work with: Chris Lauber, Xiaoyu Zhang

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: chris.lauber@twincore.de (CL); a.e.gorbalenya@lumc.nl (AEG); s.seitz@dkfz-heidelberg.de (SS)

  Affiliations Institute for Experimental Virology, TWINCORE Centre for Experimental and Clinical Infection Research, a joint venture between the Hannover Medical School (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany, Cluster of Excellence 2155 RESIST, Hannover, Germany

  https://orcid.org/0000-0002-2265-2953

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• Xiaoyu Zhang ,

  Contributed equally to this work with: Chris Lauber, Xiaoyu Zhang

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliation Institute for Experimental Virology, TWINCORE Centre for Experimental and Clinical Infection Research, a joint venture between the Hannover Medical School (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany

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• Josef Vaas,

  Roles Formal analysis

  Affiliations Division of Virus-Associated Carcinogenesis (F170), German Cancer Research Center (DKFZ), Heidelberg, Germany, Heidelberg University, Medical Faculty Heidelberg, Department of Infectious Diseases, Molecular Virology, Center for Integrative Infectious Disease Research, Heidelberg, Germany

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• Franziska Klingler,

  Roles Formal analysis

  Affiliations Division of Virus-Associated Carcinogenesis (F170), German Cancer Research Center (DKFZ), Heidelberg, Germany, Heidelberg University, Medical Faculty Heidelberg, Department of Infectious Diseases, Molecular Virology, Center for Integrative Infectious Disease Research, Heidelberg, Germany

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• Pascal Mutz,

  Roles Formal analysis, Writing – review & editing

  Current address: National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, United States

  Affiliation Division of Virus-Associated Carcinogenesis (F170), German Cancer Research Center (DKFZ), Heidelberg, Germany

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• Arseny Dubin,

  Roles Data curation

  Affiliation Marine Evolutionary Biology, Zoological Institute, Kiel University, Kiel, Germany

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• Thomas Pietschmann,

  Roles Funding acquisition, Project administration, Resources, Writing – review & editing

  Affiliations Institute for Experimental Virology, TWINCORE Centre for Experimental and Clinical Infection Research, a joint venture between the Hannover Medical School (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany, Cluster of Excellence 2155 RESIST, Hannover, Germany

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• Olivia Roth,

  Roles Resources, Writing – review & editing

  Affiliation Marine Evolutionary Biology, Zoological Institute, Kiel University, Kiel, Germany

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• Benjamin W. Neuman,

  Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliation Department of Biology and Texas A&M Global Health Research Complex, Texas A&M University, College Station, Texas, United States

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• Alexander E. Gorbalenya ,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

  * E-mail: chris.lauber@twincore.de (CL); a.e.gorbalenya@lumc.nl (AEG); s.seitz@dkfz-heidelberg.de (SS)

  Affiliations Leiden University Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands, Faculty of Bioengineering and Bioinformatics and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia

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• Ralf Bartenschlager,

  Roles Funding acquisition, Project administration, Writing – review & editing

  Affiliations Division of Virus-Associated Carcinogenesis (F170), German Cancer Research Center (DKFZ), Heidelberg, Germany, Heidelberg University, Medical Faculty Heidelberg, Department of Infectious Diseases, Molecular Virology, Center for Integrative Infectious Disease Research, Heidelberg, Germany

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• Stefan Seitz

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – review & editing

  * E-mail: chris.lauber@twincore.de (CL); a.e.gorbalenya@lumc.nl (AEG); s.seitz@dkfz-heidelberg.de (SS)

  Affiliations Division of Virus-Associated Carcinogenesis (F170), German Cancer Research Center (DKFZ), Heidelberg, Germany, Heidelberg University, Medical Faculty Heidelberg, Department of Infectious Diseases, Molecular Virology, Center for Integrative Infectious Disease Research, Heidelberg, Germany

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