Metabolic changes enhance necroptosis of type 2 diabetes mellitus mice infected with Mycobacterium tuberculosis

Abhinav Vankayalapati; Olamipejo Durojaye; Tanmoy Mukherjee; Padmaja Paidipally; Bismark Owusu-Afriyie; Ramakrishna Vankayalapati; Rajesh Kumar Radhakrishnan

doi:10.1371/journal.ppat.1012148

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Open Access

Peer-reviewed

Research Article

Metabolic changes enhance necroptosis of type 2 diabetes mellitus mice infected with Mycobacterium tuberculosis

Abhinav Vankayalapati ,

Contributed equally to this work with: Abhinav Vankayalapati, Olamipejo Durojaye

Roles Data curation, Investigation, Methodology

Affiliation Center for Biomedical Research, The University of Texas Health Science Center at Tyler, Tyler, Texas, United States of America
⨯
Olamipejo Durojaye ,

Contributed equally to this work with: Abhinav Vankayalapati, Olamipejo Durojaye

Roles Data curation, Investigation, Methodology

Affiliation Center for Biomedical Research, The University of Texas Health Science Center at Tyler, Tyler, Texas, United States of America
⨯
Tanmoy Mukherjee,

Roles Investigation, Methodology

Affiliation Center for Biomedical Research, The University of Texas Health Science Center at Tyler, Tyler, Texas, United States of America
⨯
Padmaja Paidipally,

Roles Investigation, Methodology

Affiliation Center for Biomedical Research, The University of Texas Health Science Center at Tyler, Tyler, Texas, United States of America
⨯
Bismark Owusu-Afriyie,

Roles Investigation, Methodology

Affiliation Center for Biomedical Research, The University of Texas Health Science Center at Tyler, Tyler, Texas, United States of America
⨯
Ramakrishna Vankayalapati,

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

Affiliation Center for Biomedical Research, The University of Texas Health Science Center at Tyler, Tyler, Texas, United States of America
⨯
Rajesh Kumar Radhakrishnan

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: rajeshmb07@gmail.com, rajesh.radhakrishnan@uttyler.edu

Affiliation Center for Biomedical Research, The University of Texas Health Science Center at Tyler, Tyler, Texas, United States of America

https://orcid.org/0000-0003-4664-287X

⨯

Metabolic changes enhance necroptosis of type 2 diabetes mellitus mice infected with Mycobacterium tuberculosis

Abhinav Vankayalapati,
Olamipejo Durojaye,
Tanmoy Mukherjee,
Padmaja Paidipally,
Bismark Owusu-Afriyie,
Ramakrishna Vankayalapati,
Rajesh Kumar Radhakrishnan

Published: May 10, 2024
https://doi.org/10.1371/journal.ppat.1012148

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Alveolar macrophages
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Mycobacterium tuberculosis
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Type 2 diabetes
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Pyridoxine
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Metabolites
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Apoptosis
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Mouse models
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Necrotic cell death
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