African swine fever virus pB318L, a trans-geranylgeranyl-diphosphate synthase, negatively regulates cGAS-STING and IFNAR-JAK-STAT signaling pathways

• Xiaohong Liu ,

  Contributed equally to this work with: Xiaohong Liu, Hefeng Chen

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

  Affiliation National African Swine Fever Para-reference Laboratory, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China

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• Hefeng Chen ,

  Contributed equally to this work with: Xiaohong Liu, Hefeng Chen

  Roles Formal analysis, Investigation

  Affiliation National African Swine Fever Para-reference Laboratory, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China

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• Guangqiang Ye,

  Roles Methodology, Writing – review & editing

  Affiliation National African Swine Fever Para-reference Laboratory, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China

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• Hongyang Liu,

  Roles Methodology, Writing – review & editing

  Affiliation National African Swine Fever Para-reference Laboratory, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China

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• Chunying Feng,

  Roles Writing – review & editing

  Affiliation National African Swine Fever Para-reference Laboratory, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China

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• Weiye Chen,

  Roles Resources, Writing – review & editing

  Affiliation National African Swine Fever Para-reference Laboratory, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China

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• Liang Hu,

  Roles Writing – review & editing

  Affiliation National African Swine Fever Para-reference Laboratory, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China

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• Qiongqiong Zhou,

  Roles Writing – review & editing

  Affiliation National African Swine Fever Para-reference Laboratory, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China

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• Zhaoxia Zhang,

  Roles Writing – review & editing

  Affiliations National African Swine Fever Para-reference Laboratory, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China, Heilongjiang Provincial Key Laboratory of Veterinary Immunology, Harbin, China

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• Jiangnan Li,

  Roles Writing – review & editing

  Affiliations National African Swine Fever Para-reference Laboratory, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China, Heilongjiang Provincial Key Laboratory of Veterinary Immunology, Harbin, China

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• Xianfeng Zhang,

  Roles Resources

  Affiliation National African Swine Fever Para-reference Laboratory, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China

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• Xijun He,

  Roles Resources

  Affiliation National African Swine Fever Para-reference Laboratory, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China

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• Yuntao Guan,

  Roles Resources

  Affiliation National African Swine Fever Para-reference Laboratory, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China

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• Zhengshuang Wu,

  Roles Writing – review & editing

  Affiliation National African Swine Fever Para-reference Laboratory, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China

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• Dongming Zhao,

  Roles Resources

  Affiliation National African Swine Fever Para-reference Laboratory, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China

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• Zhigao Bu ,

  Roles Supervision

  * E-mail: buzhigao@caas.cn (ZB); wengchangjiang@caas.cn (CW); huangli02@caas.cn (LH)

  Affiliation National African Swine Fever Para-reference Laboratory, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China

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• Changjiang Weng ,

  Roles Conceptualization, Funding acquisition, Project administration, Supervision

  * E-mail: buzhigao@caas.cn (ZB); wengchangjiang@caas.cn (CW); huangli02@caas.cn (LH)

  Affiliations National African Swine Fever Para-reference Laboratory, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China, Heilongjiang Provincial Key Laboratory of Veterinary Immunology, Harbin, China

  https://orcid.org/0000-0002-7676-9030

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•  [ ... ],
• Li Huang

  Roles Conceptualization, Data curation, Funding acquisition, Project administration

  * E-mail: buzhigao@caas.cn (ZB); wengchangjiang@caas.cn (CW); huangli02@caas.cn (LH)

  Affiliations National African Swine Fever Para-reference Laboratory, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China, Heilongjiang Provincial Key Laboratory of Veterinary Immunology, Harbin, China

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