A novel sORF gene mutant strain of Yersinia pestis vaccine EV76 offers enhanced safety and improved protection against plague

• Xiao Guo ,

  Contributed equally to this work with: Xiao Guo, Youquan Xin, Zehui Tong

  Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

  Affiliation State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China

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• Youquan Xin ,

  Contributed equally to this work with: Xiao Guo, Youquan Xin, Zehui Tong

  Roles Data curation, Funding acquisition, Methodology

  Affiliation Key Laboratory for Plague Prevention and Control of Qinghai Province, Qinghai Institute for Endemic Disease Prevention and Control, Xining, China

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• Zehui Tong ,

  Contributed equally to this work with: Xiao Guo, Youquan Xin, Zehui Tong

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation

  Affiliation School of Basic Medical Sciences, Anhui Medical University Hefei, China

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• Shiyang Cao,

  Roles Methodology, Resources

  Affiliation State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China

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• Yuan Zhang,

  Roles Funding acquisition, Methodology

  Affiliation State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China

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• Gengshan Wu,

  Roles Data curation, Methodology

  Affiliation State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China

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• Hongyan Chen,

  Roles Data curation, Formal analysis, Methodology

  Affiliation State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China

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• Tong Wang,

  Roles Formal analysis, Methodology

  Affiliation State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China

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• Yajun Song,

  Roles Formal analysis, Methodology, Resources

  Affiliation State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China

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• Qingwen Zhang,

  Roles Resources

  Affiliation Key Laboratory for Plague Prevention and Control of Qinghai Province, Qinghai Institute for Endemic Disease Prevention and Control, Xining, China

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• Ruifu Yang ,

  Roles Methodology, Resources, Supervision

  * E-mail: ruifuyang@gmail.com (RY); zmduams@163.com (ZD)

  Affiliation State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China

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• Zongmin Du

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: ruifuyang@gmail.com (RY); zmduams@163.com (ZD)

  Affiliations School of Basic Medical Sciences, Anhui Medical University Hefei, China, Key Laboratory for Plague Prevention and Control of Qinghai Province, Qinghai Institute for Endemic Disease Prevention and Control, Xining, China

  https://orcid.org/0000-0002-0037-1616

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