Pyrrole-based inhibitors of RND-type efflux pumps reverse antibiotic resistance and display anti-virulence potential

• Nisha Mahey,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Clinical Microbiology & Antimicrobial Research Laboratory, CSIR-Institute of Microbial Technology, Sector 39-A, Chandigarh, India, Academy of Scientific & Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India

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• Rushikesh Tambat,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – review & editing

  Current address: Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, United States of America

  Affiliation Clinical Microbiology & Antimicrobial Research Laboratory, CSIR-Institute of Microbial Technology, Sector 39-A, Chandigarh, India

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• Ritu Kalia,

  Roles Conceptualization, Data curation, Investigation, Validation

  Affiliation Department of Natural Products, National Institute of Pharmaceutical Education and Research, Mohali, India

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• Rajnita Ingavale,

  Roles Investigation, Validation

  Affiliation Department of Natural Products, National Institute of Pharmaceutical Education and Research, Mohali, India

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• Akriti Kodesia,

  Roles Data curation, Investigation, Methodology, Visualization

  Affiliations Academy of Scientific & Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India, Structural Biology Laboratory, CSIR-Institute of Microbial Technology, Chandigarh, India

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• Nishtha Chandal,

  Roles Investigation, Validation

  Affiliations Clinical Microbiology & Antimicrobial Research Laboratory, CSIR-Institute of Microbial Technology, Sector 39-A, Chandigarh, India, Academy of Scientific & Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India

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• Srajan Kapoor,

  Roles Data curation, Investigation, Methodology, Validation, Visualization

  Affiliation Structural Biology Laboratory, CSIR-Institute of Microbial Technology, Chandigarh, India

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• Dipesh Kumar Verma,

  Roles Data curation, Investigation, Methodology, Validation, Visualization

  Current address: Department of Life Sciences and Biotechnology, Chhatrapati Shahu ji Maharaj University, Kanpur, India

  Affiliation Structural Biology Laboratory, CSIR-Institute of Microbial Technology, Chandigarh, India

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• Krishan Gopal Thakur,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation

  Affiliation Structural Biology Laboratory, CSIR-Institute of Microbial Technology, Chandigarh, India

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• Sanjay Jachak ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Validation

  * E-mail: sjachak11@gmail.com (SJ); hemraj@imtech.res.in (HN)

  Affiliation Department of Natural Products, National Institute of Pharmaceutical Education and Research, Mohali, India

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• Hemraj Nandanwar

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Validation

  * E-mail: sjachak11@gmail.com (SJ); hemraj@imtech.res.in (HN)

  Affiliations Clinical Microbiology & Antimicrobial Research Laboratory, CSIR-Institute of Microbial Technology, Sector 39-A, Chandigarh, India, Academy of Scientific & Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India

  https://orcid.org/0000-0003-4301-6355

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