BAG6 inhibits influenza A virus replication by inducing viral polymerase subunit PB2 degradation and perturbing RdRp complex assembly

• Yong Zhou,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Visualization, Writing – original draft, Writing – review & editing

  Affiliations National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China, Key Laboratory for Prevention and Control of Avian Influenza and Other Major Poultry Diseases, Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, China, Department of Preventive Veterinary, College of Veterinary Medicine, China Agricultural University, Beijing, China

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• Tian Li,

  Roles Data curation, Formal analysis, Investigation, Methodology, Resources

  Affiliations National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China, Key Laboratory for Prevention and Control of Avian Influenza and Other Major Poultry Diseases, Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, China, Department of Preventive Veterinary, College of Veterinary Medicine, China Agricultural University, Beijing, China

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• Yunfan Zhang,

  Roles Resources

  Affiliations National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China, Department of Basic Veterinary, College of Veterinary Medicine, China Agricultural University, Beijing, China

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• Nianzhi Zhang,

  Roles Formal analysis

  Affiliations National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China, Department of Preventive Veterinary, College of Veterinary Medicine, China Agricultural University, Beijing, China

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• Yuxin Guo,

  Roles Investigation

  Affiliations National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China, Key Laboratory for Prevention and Control of Avian Influenza and Other Major Poultry Diseases, Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, China, Department of Preventive Veterinary, College of Veterinary Medicine, China Agricultural University, Beijing, China

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• Xiaoyi Gao,

  Roles Investigation

  Affiliations National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China, Key Laboratory for Prevention and Control of Avian Influenza and Other Major Poultry Diseases, Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, China, Department of Preventive Veterinary, College of Veterinary Medicine, China Agricultural University, Beijing, China

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• Wenjing Peng,

  Roles Investigation

  Affiliations National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China, Key Laboratory for Prevention and Control of Avian Influenza and Other Major Poultry Diseases, Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, China, Department of Preventive Veterinary, College of Veterinary Medicine, China Agricultural University, Beijing, China

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• Sicheng Shu,

  Roles Investigation

  Affiliations National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China, Key Laboratory for Prevention and Control of Avian Influenza and Other Major Poultry Diseases, Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, China, Department of Preventive Veterinary, College of Veterinary Medicine, China Agricultural University, Beijing, China

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• Chuankuo Zhao,

  Roles Investigation

  Affiliations National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China, Key Laboratory for Prevention and Control of Avian Influenza and Other Major Poultry Diseases, Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, China, Department of Preventive Veterinary, College of Veterinary Medicine, China Agricultural University, Beijing, China

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• Di Cui,

  Roles Resources

  Affiliations National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China, Department of Basic Veterinary, College of Veterinary Medicine, China Agricultural University, Beijing, China

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• Honglei Sun,

  Roles Writing – review & editing

  Affiliations National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China, Key Laboratory for Prevention and Control of Avian Influenza and Other Major Poultry Diseases, Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, China, Department of Preventive Veterinary, College of Veterinary Medicine, China Agricultural University, Beijing, China

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• Yipeng Sun,

  Roles Writing – review & editing

  Affiliations National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China, Key Laboratory for Prevention and Control of Avian Influenza and Other Major Poultry Diseases, Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, China, Department of Preventive Veterinary, College of Veterinary Medicine, China Agricultural University, Beijing, China

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• Jinhua Liu,

  Roles Funding acquisition, Writing – review & editing

  Affiliations National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China, Key Laboratory for Prevention and Control of Avian Influenza and Other Major Poultry Diseases, Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, China, Department of Preventive Veterinary, College of Veterinary Medicine, China Agricultural University, Beijing, China

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• Jun Tang,

  Roles Writing – review & editing

  Affiliations National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China, Department of Basic Veterinary, College of Veterinary Medicine, China Agricultural University, Beijing, China

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• Rui Zhang ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: 2015001@cau.edu.cn (RZ); pujuan@cau.edu.cn (JP)

  Affiliations National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China, Department of Basic Veterinary, College of Veterinary Medicine, China Agricultural University, Beijing, China

  https://orcid.org/0000-0001-9015-0819

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•  [ ... ],
• Juan Pu

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Writing – review & editing

  * E-mail: 2015001@cau.edu.cn (RZ); pujuan@cau.edu.cn (JP)

  Affiliations National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China, Key Laboratory for Prevention and Control of Avian Influenza and Other Major Poultry Diseases, Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, China, Department of Preventive Veterinary, College of Veterinary Medicine, China Agricultural University, Beijing, China

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