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Open Access
Peer-reviewed
Research Article
NLRP3 and AIM2 inflammasomes exacerbate the pathogenic Th17 cell response to eggs of the helminth Schistosoma mansoni
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Madhusoodhanan Suresh Kumar Meena Kumari ,
Contributed equally to this work with: Madhusoodhanan Suresh Kumar Meena Kumari, Pengyu Liu
Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation
Affiliation Department of Veterinary and Biomedical Sciences, Center for Molecular Immunology and Infectious Disease, Pennsylvania State University, University Park, Pennsylvania, United States of America
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Pengyu Liu ,
Contributed equally to this work with: Madhusoodhanan Suresh Kumar Meena Kumari, Pengyu Liu
Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation
Affiliation Department of Veterinary and Biomedical Sciences, Center for Molecular Immunology and Infectious Disease, Pennsylvania State University, University Park, Pennsylvania, United States of America
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Megan S. Nitchman,
Roles Formal analysis, Funding acquisition, Investigation, Validation
Affiliation Department of Veterinary and Biomedical Sciences, Center for Molecular Immunology and Infectious Disease, Pennsylvania State University, University Park, Pennsylvania, United States of America
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Santoshi Chaudhary,
Roles Formal analysis, Investigation, Validation
Affiliation Department of Veterinary and Biomedical Sciences, Center for Molecular Immunology and Infectious Disease, Pennsylvania State University, University Park, Pennsylvania, United States of America
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Kaile Jump,
Roles Formal analysis, Investigation, Project administration, Resources, Software, Validation
Affiliation Department of Veterinary and Biomedical Sciences, Center for Molecular Immunology and Infectious Disease, Pennsylvania State University, University Park, Pennsylvania, United States of America
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Yoelkys Morales,
Roles Formal analysis, Investigation, Methodology, Resources, Software, Validation
Affiliation Department of Immunology, Tufts University School of Medicine, Boston, Massachusetts, United States of America
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Emily A. Miller,
Roles Formal analysis, Investigation, Methodology, Resources, Software, Validation
Affiliation Department of Immunology, Tufts University School of Medicine, Boston, Massachusetts, United States of America
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Ilana Shecter,
Roles Formal analysis, Investigation, Methodology, Resources, Software, Validation
Affiliation Department of Immunology, Tufts University School of Medicine, Boston, Massachusetts, United States of America
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Miguel J. Stadecker,
Roles Funding acquisition, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing
Affiliation Department of Immunology, Tufts University School of Medicine, Boston, Massachusetts, United States of America
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Parisa Kalantari
Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing
* E-mail: puk103@psu.edu
Affiliations Department of Veterinary and Biomedical Sciences, Center for Molecular Immunology and Infectious Disease, Pennsylvania State University, University Park, Pennsylvania, United States of America, Department of Immunology, Tufts University School of Medicine, Boston, Massachusetts, United States of America
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NLRP3 and AIM2 inflammasomes exacerbate the pathogenic Th17 cell response to eggs of the helminth Schistosoma mansoni
- Madhusoodhanan Suresh Kumar Meena Kumari,
- Pengyu Liu,
- Megan S. Nitchman,
- Santoshi Chaudhary,
- Kaile Jump,
- Yoelkys Morales,
- Emily A. Miller,
- Ilana Shecter,
- Miguel J. Stadecker,
- Parisa Kalantari
- Published: March 18, 2025
- https://doi.org/10.1371/journal.ppat.1012108