A genome-wide CRISPR screening uncovers that TOB1 acts as a key host factor for FMDV infection via both IFN and EGFR mediated pathways

• Gaochuang Peng ,

  Contributed equally to this work with: Gaochuang Peng, Tianran Liu, Xiaolan Qi

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Writing – original draft, Writing – review & editing

  Affiliations State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, Frontiers Science Center for Molecular Design Breeding, China Agricultural University, Beijing, China, State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China

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• Tianran Liu ,

  Contributed equally to this work with: Gaochuang Peng, Tianran Liu, Xiaolan Qi

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology

  Affiliations State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, Frontiers Science Center for Molecular Design Breeding, China Agricultural University, Beijing, China, State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China

  ⨯
• Xiaolan Qi ,

  Contributed equally to this work with: Gaochuang Peng, Tianran Liu, Xiaolan Qi

  Roles Conceptualization, Data curation, Formal analysis, Methodology

  Affiliation State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China

  ⨯
• Yuzhe Wang,

  Roles Data curation, Formal analysis, Resources

  Affiliation State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, Frontiers Science Center for Molecular Design Breeding, China Agricultural University, Beijing, China

  ⨯
• Jingjing Ren,

  Roles Data curation, Formal analysis

  Affiliation State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China

  ⨯
• Jiangling Peng,

  Roles Data curation, Formal analysis

  Affiliation State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China

  ⨯
• Xuguang Du,

  Roles Data curation, Formal analysis

  Affiliation State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, Frontiers Science Center for Molecular Design Breeding, China Agricultural University, Beijing, China

  ⨯
• Siyu Hu,

  Roles Data curation, Formal analysis

  Affiliation State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, Frontiers Science Center for Molecular Design Breeding, China Agricultural University, Beijing, China

  ⨯
• Sen Wu ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration

  * E-mail: swu@cau.edu.cn (SW); yaofengzhao@cau.edu.cn (YZ); lidan@caas.cn (DL); haixuezheng@163.com (HZ)

  Affiliation State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, Frontiers Science Center for Molecular Design Breeding, China Agricultural University, Beijing, China

  https://orcid.org/0000-0003-0764-6122

  ⨯
• Yaofeng Zhao ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Writing – review & editing

  * E-mail: swu@cau.edu.cn (SW); yaofengzhao@cau.edu.cn (YZ); lidan@caas.cn (DL); haixuezheng@163.com (HZ)

  Affiliation State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, Frontiers Science Center for Molecular Design Breeding, China Agricultural University, Beijing, China

  https://orcid.org/0000-0003-4499-8610

  ⨯
• Dan Li ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Writing – review & editing

  * E-mail: swu@cau.edu.cn (SW); yaofengzhao@cau.edu.cn (YZ); lidan@caas.cn (DL); haixuezheng@163.com (HZ)

  Affiliation State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China

  https://orcid.org/0000-0002-4831-5103

  ⨯
• Haixue Zheng

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Supervision, Validation, Writing – review & editing

  * E-mail: swu@cau.edu.cn (SW); yaofengzhao@cau.edu.cn (YZ); lidan@caas.cn (DL); haixuezheng@163.com (HZ)

  Affiliation State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China

  https://orcid.org/0000-0002-1644-2300

  ⨯