Coronavirus nucleocapsid protein enhances the binding of p-PKCα to RACK1: Implications for inhibition of nucleocytoplasmic trafficking and suppression of the innate immune response

Wenxiang Xue; Hongyan Chu; Jiehuang Wang; Yingjie Sun; Xusheng Qiu; Cuiping Song; Lei Tan; Chan Ding; Ying Liao

doi:10.1371/journal.ppat.1012097

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Open Access

Peer-reviewed

Research Article

Coronavirus nucleocapsid protein enhances the binding of p-PKCα to RACK1: Implications for inhibition of nucleocytoplasmic trafficking and suppression of the innate immune response

Wenxiang Xue,

Roles Conceptualization, Formal analysis, Investigation, Writing – original draft

Affiliation Department of Avian Infectious Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, P. R. China
⨯
Hongyan Chu,

Roles Investigation

Affiliation Department of Avian Infectious Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, P. R. China
⨯
Jiehuang Wang,

Roles Investigation

Affiliation Department of Avian Infectious Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, P. R. China
⨯
Yingjie Sun,

Roles Resources, Supervision

Affiliation Department of Avian Infectious Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, P. R. China
⨯
Xusheng Qiu,

Roles Resources

Affiliation Department of Avian Infectious Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, P. R. China
⨯
Cuiping Song,

Roles Resources

Affiliation Department of Avian Infectious Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, P. R. China
⨯
Lei Tan,

Roles Resources

Affiliation Department of Avian Infectious Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, P. R. China
⨯
Chan Ding,

Roles Funding acquisition, Project administration, Supervision

Affiliations Department of Avian Infectious Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, P. R. China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, P. R. China
⨯
Ying Liao

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: liaoying@shvri.ac.cn

Affiliation Department of Avian Infectious Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, P. R. China

https://orcid.org/0000-0001-7906-7918

⨯

Coronavirus nucleocapsid protein enhances the binding of p-PKCα to RACK1: Implications for inhibition of nucleocytoplasmic trafficking and suppression of the innate immune response

Wenxiang Xue,
Hongyan Chu,
Jiehuang Wang,
Yingjie Sun,
Xusheng Qiu,
Cuiping Song,
Lei Tan,
Chan Ding,
Ying Liao

Published: November 27, 2024
https://doi.org/10.1371/journal.ppat.1012097

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