An LIR motif in the Rift Valley fever virus NSs protein is critical for the interaction with LC3 family members and inhibition of autophagy

• Kaylee Petraccione ,

  Contributed equally to this work with: Kaylee Petraccione, Mohamed G. H. Ali

  Roles Formal analysis, Investigation, Methodology, Writing – original draft

  Affiliations Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America, Center for Emerging, Zoonotic, and Arthropod-borne Pathogens, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America

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• Mohamed G. H. Ali ,

  Contributed equally to this work with: Kaylee Petraccione, Mohamed G. H. Ali

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliations Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Quebec, Canada, Department of Biochemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt

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• Normand Cyr,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Quebec, Canada

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• Haytham M. Wahba,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliations Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Quebec, Canada, Department of Biochemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt

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• Timothy Stocker,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America

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• Maryna Akhrymuk,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliations Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America, Center for Emerging, Zoonotic, and Arthropod-borne Pathogens, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America

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• Ivan Akhrymuk,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliations Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America, Center for Emerging, Zoonotic, and Arthropod-borne Pathogens, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America

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• Lauren Panny,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliations Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America, Center for Emerging, Zoonotic, and Arthropod-borne Pathogens, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America

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• Nicole Bracci,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliations Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America, Center for Emerging, Zoonotic, and Arthropod-borne Pathogens, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America

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• Raphaël Cafaro,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliations Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Quebec, Canada, Department of Biochemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt

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• Danuta Sastre,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Biosciences Division, SRI International, Menlo Park, California, United States of America

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• Andrew Silberfarb,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Writing – review & editing

  Affiliation Artificial Intelligence Center, SRI International, Menlo Park, California, United States of America

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• Paul O’Maille,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Writing – review & editing

  Affiliation Biosciences Division, SRI International, Menlo Park, California, United States of America

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• James Omichinski ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – review & editing

  * E-mail: jg.omichinski@umontreal.ca (JO); kkehnhall@vt.edu (KKH)

  Affiliation Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Quebec, Canada

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• Kylene Kehn-Hall

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

  * E-mail: jg.omichinski@umontreal.ca (JO); kkehnhall@vt.edu (KKH)

  Affiliations Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America, Center for Emerging, Zoonotic, and Arthropod-borne Pathogens, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America

  https://orcid.org/0000-0001-8036-7213

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