Loxapine inhibits replication of hepatitis A virus in vitro and in vivo by targeting viral protein 2C

• Mami Matsuda ,

  Contributed equally to this work with: Mami Matsuda, Asuka Hirai-Yuki, Osamu Kotani

  Roles Conceptualization, Formal analysis, Investigation, Writing – review & editing

  Affiliation Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan

  ⨯
• Asuka Hirai-Yuki ,

  Contributed equally to this work with: Mami Matsuda, Asuka Hirai-Yuki, Osamu Kotani

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Writing – review & editing

  Affiliation Management Department of Biosafety, Laboratory Animal, and Pathogen Bank, National Institute of Infectious Diseases, Tokyo, Japan

  ⨯
• Osamu Kotani ,

  Contributed equally to this work with: Mami Matsuda, Asuka Hirai-Yuki, Osamu Kotani

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Pathogen Genomics Center, National Institute for Infectious Diseases, Tokyo, Japan

  ⨯
• Michiyo Kataoka,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan

  ⨯
• Xin Zheng,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan

  ⨯
• Daisuke Yamane,

  Roles Methodology, Resources, Writing – review & editing

  Affiliation Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan

  ⨯
• Masaru Yokoyama,

  Roles Supervision, Writing – review & editing

  Affiliation Pathogen Genomics Center, National Institute for Infectious Diseases, Tokyo, Japan

  ⨯
• Koji Ishii,

  Roles Resources, Supervision, Writing – review & editing

  Affiliation Department of Quality Assurance, Radiation Safety, and Information System, National Institute of Infectious Diseases, Tokyo, Japan

  ⨯
• Masamichi Muramatsu,

  Roles Supervision, Writing – review & editing

  Affiliations Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan, Department of Infectious Disease Research, Foundation for Biomedical Research and Innovation at Kobe, Kobe, Japan

  ⨯
• Ryosuke Suzuki

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: ryosuke@niid.go.jp

  Affiliations Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan, Department of Biological Science and Technology, Faculty of Advanced Engineering, Tokyo University of Science, Tokyo, Japan

  ⨯