Anti-prion drugs do not improve survival in novel knock-in models of inherited prion disease

• Daniel J. Walsh,

  Roles Data curation, Investigation, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Biochemistry and Cell Biology Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America

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• Judy R. Rees,

  Roles Formal analysis, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliations Department of Epidemiology Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America, Department of Community and Family Medicine Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America

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• Surabhi Mehra,

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada

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• Matthew E. C. Bourkas,

  Roles Investigation, Resources, Writing – review & editing

  Affiliations Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada, Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada

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• Lech Kaczmarczyk,

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Wallenberg Center for Molecular Medicine, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden

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• Erica Stuart,

  Roles Investigation, Resources, Writing – review & editing

  Affiliations Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada, Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada

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• Walker S. Jackson,

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Wallenberg Center for Molecular Medicine, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden

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• Joel C. Watts,

  Roles Investigation, Resources, Writing – review & editing

  Affiliations Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada, Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada

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• Surachai Supattapone

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: supattapone@dartmouth.edu

  Affiliations Department of Biochemistry and Cell Biology Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America, Department of Medicine, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America

  https://orcid.org/0000-0001-9060-4550

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