Microtubule disruption synergizes with STING signaling to show potent and broad-spectrum antiviral activity

Jing Han; Zhimeng Wang; Fangping Han; Bo Peng; Juanjuan Du; Conggang Zhang

doi:10.1371/journal.ppat.1012048

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Open Access

Peer-reviewed

Research Article

Microtubule disruption synergizes with STING signaling to show potent and broad-spectrum antiviral activity

Jing Han ,

Contributed equally to this work with: Jing Han, Zhimeng Wang

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations State Key Laboratory of Membrane Biology, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China, Tsinghua-Peking Center for Life Sciences, Beijing, China
⨯
Zhimeng Wang ,

Contributed equally to this work with: Jing Han, Zhimeng Wang

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

Affiliations State Key Laboratory of Membrane Biology, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China, Tsinghua-Peking Center for Life Sciences, Beijing, China
⨯
Fangping Han,

Roles Investigation, Methodology, Validation

Affiliations State Key Laboratory of Membrane Biology, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China, Tsinghua-Peking Center for Life Sciences, Beijing, China
⨯
Bo Peng,

Roles Resources

Affiliation Department of Microbiology Laboratory, Shenzhen Center for Disease Control and Prevention, Shenzhen, China
⨯
Juanjuan Du,

Roles Resources, Writing – review & editing

Affiliations State Key Laboratory of Membrane Biology, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China, MOE Key Laboratory of Bioorganic Phosphorus Chemistry &Chemical Biology, Tsinghua University Beijing, China
⨯
Conggang Zhang

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: cgzhang@tsinghua.edu.cn.

Affiliations State Key Laboratory of Membrane Biology, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China, Tsinghua-Peking Center for Life Sciences, Beijing, China

https://orcid.org/0000-0003-0282-1921

⨯

Microtubule disruption synergizes with STING signaling to show potent and broad-spectrum antiviral activity

Jing Han,
Zhimeng Wang,
Fangping Han,
Bo Peng,
Juanjuan Du,
Conggang Zhang

Published: February 26, 2024
https://doi.org/10.1371/journal.ppat.1012048

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Microtubules
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Immune response
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Antiviral therapy
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Antiviral immune response
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Immunoblotting
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Enzyme-linked immunoassays
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Viral transmission and infection
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Phosphorylation
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