A tick saliva serpin, IxsS17 inhibits host innate immune system proteases and enhances host colonization by Lyme disease agent

• Thu-Thuy Nguyen,

  Roles Conceptualization, Data curation, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Veterinary Pathobiology, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, United States of America

  https://orcid.org/0009-0009-3678-9414

  ⨯
• Tae Heung Kim,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Veterinary Pathobiology, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, United States of America

  ⨯
• Emily Bencosme-Cuevas,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Veterinary Pathobiology, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, United States of America

  ⨯
• Jacquie Berry,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Veterinary Pathobiology, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, United States of America

  ⨯
• Alex Samuel Kiarie Gaithuma,

  Roles Formal analysis, Writing – review & editing

  Affiliation Department of Veterinary Pathobiology, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, United States of America

  ⨯
• Moiz Ashraf Ansari,

  Roles Formal analysis, Visualization, Writing – review & editing

  Affiliation Department of Veterinary Pathobiology, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, United States of America

  ⨯
• Tae Kwon Kim,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, United States of America

  ⨯
• Lucas Tirloni,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Tick-Pathogen Transmission Unit, Laboratory of Bacteriology, NIAID, Hamilton, Montana, United States of America

  ⨯
• Zeljko Radulovic,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Department of Biology, Stephen F. Austin State University, Nacogdoches, Texas, United States of America

  ⨯
• James J. Moresco,

  Roles Funding acquisition, Validation, Writing – review & editing

  Affiliation Center for Genetics of Host Defense, UT Southwestern Medical Center, Dallas, Texas, United States of America

  ⨯
• John R. Yates III,

  Roles Funding acquisition, Writing – review & editing

  Affiliation Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, United States of America

  ⨯
• Albert Mulenga

  Roles Conceptualization, Funding acquisition, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: amulenga@cvm.tamu.edu

  Affiliation Department of Veterinary Pathobiology, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, United States of America

  https://orcid.org/0000-0002-5029-1198

  ⨯