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Open Access
Peer-reviewed
Research Article
Candida albicans translocation through the intestinal epithelial barrier is promoted by fungal zinc acquisition and limited by NFκB-mediated barrier protection
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Jakob L. Sprague,
Roles Conceptualization, Data curation, Investigation, Methodology, Project administration, Validation, Writing – original draft, Writing – review & editing
Affiliation Department of Microbial Pathogenicity Mechanisms, Hans-Knöll-Institute, Jena, Germany
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Tim B. Schille,
Roles Data curation, Formal analysis, Methodology, Writing – review & editing
Affiliations Department of Microbial Pathogenicity Mechanisms, Hans-Knöll-Institute, Jena, Germany, Cluster of Excellence Balance of the Microverse, Friedrich-Schiller-University Jena, Jena, Germany
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Stefanie Allert,
Roles Data curation, Methodology, Writing – review & editing
Affiliation Department of Microbial Pathogenicity Mechanisms, Hans-Knöll-Institute, Jena, Germany
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Verena Trümper,
Roles Data curation, Formal analysis, Methodology, Writing – review & editing
Affiliation Department of Microbial Pathogenicity Mechanisms, Hans-Knöll-Institute, Jena, Germany
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Adrian Lier,
Roles Data curation, Methodology, Writing – review & editing
Affiliation Department of Microbial Pathogenicity Mechanisms, Hans-Knöll-Institute, Jena, Germany
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Peter Großmann,
Roles Data curation, Formal analysis, Software, Writing – review & editing
Affiliation Department of Microbiome Dynamics, Hans-Knöll-Institute, Jena, Germany
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Emily L. Priest,
Roles Data curation, Methodology, Writing – review & editing
Affiliation Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King’s College London, London, United Kingdom
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Antzela Tsavou,
Roles Data curation, Methodology, Writing – review & editing
Affiliation Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King’s College London, London, United Kingdom
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Gianni Panagiotou,
Roles Conceptualization, Project administration, Writing – review & editing
Affiliations Cluster of Excellence Balance of the Microverse, Friedrich-Schiller-University Jena, Jena, Germany, Department of Microbiome Dynamics, Hans-Knöll-Institute, Jena, Germany, Institute of Microbiology, Friedrich-Schiller-University Jena, Jena, Germany
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Julian R. Naglik,
Roles Conceptualization, Project administration, Writing – review & editing
Affiliation Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King’s College London, London, United Kingdom
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Duncan Wilson,
Roles Conceptualization, Project administration, Writing – review & editing
Affiliation Medical Research Council, Centre for Medical Mycology at the University of Exeter, Exeter, United Kingdom
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Sascha Schäuble,
Roles Data curation, Formal analysis, Methodology, Project administration, Software, Writing – review & editing
Affiliation Department of Microbiome Dynamics, Hans-Knöll-Institute, Jena, Germany
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Lydia Kasper ,
Contributed equally to this work with: Lydia Kasper, Bernhard Hube
Roles Conceptualization, Data curation, Investigation, Project administration, Supervision, Writing – original draft, Writing – review & editing
Affiliation Department of Microbial Pathogenicity Mechanisms, Hans-Knöll-Institute, Jena, Germany
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Bernhard Hube
Contributed equally to this work with: Lydia Kasper, Bernhard Hube
Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – review & editing
* E-mail: bernhard.hube@leibniz-hki.de
Affiliations Department of Microbial Pathogenicity Mechanisms, Hans-Knöll-Institute, Jena, Germany, Cluster of Excellence Balance of the Microverse, Friedrich-Schiller-University Jena, Jena, Germany, Institute of Microbiology, Friedrich-Schiller-University Jena, Jena, Germany
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Candida albicans translocation through the intestinal epithelial barrier is promoted by fungal zinc acquisition and limited by NFκB-mediated barrier protection
- Jakob L. Sprague,
- Tim B. Schille,
- Stefanie Allert,
- Verena Trümper,
- Adrian Lier,
- Peter Großmann,
- Emily L. Priest,
- Antzela Tsavou,
- Gianni Panagiotou,
- Julian R. Naglik
- Published: March 1, 2024
- https://doi.org/10.1371/journal.ppat.1012031