Hepatitis B virus RNAs co-opt ELAVL1 for stabilization and CRM1-dependent nuclear export

Yingcheng Zheng; Mengfei Wang; Jiatong Yin; Yurong Duan; Chuanjian Wu; Zaichao Xu; Yanan Bu; Jingjing Wang; Quan Chen; Guoguo Zhu; Kaitao Zhao; Lu Zhang; Rong Hua; Yanping Xu; Xiyu Hu; Xiaoming Cheng; Yuchen Xia

doi:10.1371/journal.ppat.1011999

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Open Access

Peer-reviewed

Research Article

Hepatitis B virus RNAs co-opt ELAVL1 for stabilization and CRM1-dependent nuclear export

Yingcheng Zheng ,

Contributed equally to this work with: Yingcheng Zheng, Mengfei Wang

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

Affiliations State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China, School of Life Sciences, Hubei University, Wuhan, China
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Mengfei Wang ,

Contributed equally to this work with: Yingcheng Zheng, Mengfei Wang

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

Affiliation State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China
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Jiatong Yin,

Roles Data curation, Formal analysis, Investigation, Visualization

Affiliation State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China
⨯
Yurong Duan,

Roles Data curation, Formal analysis, Investigation

Affiliation State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China
⨯
Chuanjian Wu,

Roles Data curation, Formal analysis, Investigation

Affiliation State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China
⨯
Zaichao Xu,

Roles Data curation, Formal analysis, Investigation

Affiliation State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China
⨯
Yanan Bu,

Roles Data curation, Formal analysis, Investigation

Affiliation State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China
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Jingjing Wang,

Roles Data curation, Methodology

Affiliation State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China
⨯
Quan Chen,

Roles Data curation, Formal analysis, Methodology

Affiliation State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China
⨯
Guoguo Zhu,

Roles Data curation, Methodology

Affiliation Department of Emergency, General Hospital of Central Theater Command of People’s Liberation Army of China, Wuhan, China
⨯
Kaitao Zhao,

Roles Data curation, Methodology

Affiliation State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China
⨯
Lu Zhang,

Roles Investigation

Affiliation State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China
⨯
Rong Hua,

Roles Data curation, Methodology

Affiliation State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China
⨯
Yanping Xu,

Roles Data curation, Methodology

Affiliation State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China
⨯
Xiyu Hu,

Roles Methodology

Affiliation State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China
⨯
Xiaoming Cheng,

Roles Funding acquisition, Writing – review & editing

Affiliations State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China, Department of Pathology, Zhongnan Hospital of Wuhan University, Wuhan, China, Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Diseases, Wuhan, China, Hubei Jiangxia Laboratory, Wuhan, China
⨯
[ ... ],
Yuchen Xia

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: yuchenxia@whu.edu.cn

Affiliations State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China, Hubei Jiangxia Laboratory, Wuhan, China, Pingyuan Laboratory, Henan, China

https://orcid.org/0000-0001-8460-3893

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Hepatitis B virus RNAs co-opt ELAVL1 for stabilization and CRM1-dependent nuclear export

Yingcheng Zheng,
Mengfei Wang,
Jiatong Yin,
Yurong Duan,
Chuanjian Wu,
Zaichao Xu,
Yanan Bu,
Jingjing Wang,
Quan Chen,
Guoguo Zhu

Published: February 2, 2024
https://doi.org/10.1371/journal.ppat.1011999

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