Neutralizing monoclonal antibodies against the Gc fusion loop region of Crimean–Congo hemorrhagic fever virus

Liushuai Li; Tingting Chong; Lu Peng; Yajie Liu; Guibo Rao; Yan Fu; Yanni Shu; Jiamei Shen; Qinghong Xiao; Jia Liu; Jiang Li; Fei Deng; Bing Yan; Zhihong Hu; Sheng Cao; Manli Wang

doi:10.1371/journal.ppat.1011948

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Open Access

Peer-reviewed

Research Article

Neutralizing monoclonal antibodies against the Gc fusion loop region of Crimean–Congo hemorrhagic fever virus

Liushuai Li ,

Contributed equally to this work with: Liushuai Li, Tingting Chong, Lu Peng

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliations State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China, University of the Chinese Academy of Sciences, Beijing, China
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Tingting Chong ,

Contributed equally to this work with: Liushuai Li, Tingting Chong, Lu Peng

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliations State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China, University of the Chinese Academy of Sciences, Beijing, China
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Lu Peng ,

Contributed equally to this work with: Liushuai Li, Tingting Chong, Lu Peng

Roles Data curation, Investigation, Methodology

Affiliation State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China
⨯
Yajie Liu,

Roles Investigation

Affiliation State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China
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Guibo Rao,

Roles Investigation

Affiliation State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China
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Yan Fu,

Roles Investigation

Affiliation State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China
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Yanni Shu,

Roles Investigation

Affiliation State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China
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Jiamei Shen,

Roles Investigation

Affiliation State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China
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Qinghong Xiao,

Roles Investigation

Affiliation State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China
⨯
Jia Liu,

Roles Funding acquisition, Investigation

Affiliation State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China
⨯
Jiang Li,

Roles Resources

Affiliation State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China
⨯
Fei Deng,

Roles Resources

Affiliation State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China
⨯
Bing Yan,

Roles Methodology

Affiliation State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China
⨯
Zhihong Hu,

Roles Funding acquisition, Supervision, Writing – review & editing

Affiliation State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China
⨯
Sheng Cao ,

Roles Conceptualization, Methodology, Supervision, Writing – review & editing

* E-mail: caosheng@wh.iov.cn (SC); wangml@wh.iov.cn (MLW)

Affiliation State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China
⨯
[ ... ],
Manli Wang

Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – review & editing

* E-mail: caosheng@wh.iov.cn (SC); wangml@wh.iov.cn (MLW)

Affiliations State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China, Hubei Jiangxia Laboratory, Wuhan, China

https://orcid.org/0000-0001-8701-3530

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Neutralizing monoclonal antibodies against the Gc fusion loop region of Crimean–Congo hemorrhagic fever virus

Liushuai Li,
Tingting Chong,
Lu Peng,
Yajie Liu,
Guibo Rao,
Yan Fu,
Yanni Shu,
Jiamei Shen,
Qinghong Xiao,
Jia Liu

Published: February 1, 2024
https://doi.org/10.1371/journal.ppat.1011948

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