Non-canonical regulation of the reactivation of an oncogenic herpesvirus by the OTUD4-USP7 deubiquitinases

• Shaowei Wang ,

  Contributed equally to this work with: Shaowei Wang, Xuezhang Tian

  Roles Investigation, Writing – original draft, Writing – review & editing

  Affiliations State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, State Key Laboratory of Virology, Medical Research Institute, Wuhan University, Wuhan, China, Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Province Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan, China

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• Xuezhang Tian ,

  Contributed equally to this work with: Shaowei Wang, Xuezhang Tian

  Roles Investigation

  Affiliations State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, State Key Laboratory of Virology, Medical Research Institute, Wuhan University, Wuhan, China, Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China

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• Yaru Zhou,

  Roles Investigation

  Affiliations State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, State Key Laboratory of Virology, Medical Research Institute, Wuhan University, Wuhan, China, Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China

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• Jun Xie,

  Roles Formal analysis, Investigation

  Affiliations State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, State Key Laboratory of Virology, Medical Research Institute, Wuhan University, Wuhan, China, Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China

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• Ming Gao,

  Roles Investigation

  Affiliations State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, State Key Laboratory of Virology, Medical Research Institute, Wuhan University, Wuhan, China, Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China

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• Yunhong Zhong,

  Roles Investigation

  Affiliations State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, State Key Laboratory of Virology, Medical Research Institute, Wuhan University, Wuhan, China, Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China

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• Chuchu Zhang,

  Roles Investigation

  Affiliations State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, State Key Laboratory of Virology, Medical Research Institute, Wuhan University, Wuhan, China, Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China

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• Keying Yu,

  Roles Formal analysis, Methodology

  Affiliations Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China, Department of Gastrointestinal Surgery, Medical Research Institute, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China

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• Lei Bai,

  Roles Formal analysis, Methodology

  Affiliation State Key Laboratory of Virology, School of Life Sciences, Wuhan University, Wuhan, China

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• Qingsong Qin,

  Roles Formal analysis, Funding acquisition, Methodology

  Affiliation Laboratory of Human Virology and Oncology, Shantou University Medical College, Shantou, China

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• Bo Zhong,

  Roles Formal analysis, Methodology

  Affiliations Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China, Department of Gastrointestinal Surgery, Medical Research Institute, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China

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• Dandan Lin,

  Roles Formal analysis, Methodology

  Affiliation Cancer Center, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, China

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• Pinghui Feng,

  Roles Conceptualization

  Affiliation Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, United States of America

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• Ke Lan,

  Roles Conceptualization

  Affiliations Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China, State Key Laboratory of Virology, School of Life Sciences, Wuhan University, Wuhan, China

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• Junjie Zhang

  Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: junjiezhang@whu.edu.cn

  Affiliations State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, State Key Laboratory of Virology, Medical Research Institute, Wuhan University, Wuhan, China, Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Province Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan, China

  https://orcid.org/0000-0003-3812-3850

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