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Open Access
Peer-reviewed
Research Article
Structure-guided design of VAR2CSA-based immunogens and a cocktail strategy for a placental malaria vaccine
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Rui Ma,
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Writing – original draft, Writing – review & editing
Affiliation Host-Pathogen Interactions and Structural Vaccinology Section, Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Nichole D. Salinas,
Roles Investigation, Methodology, Writing – review & editing
Affiliation Host-Pathogen Interactions and Structural Vaccinology Section, Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Sachy Orr-Gonzalez,
Roles Investigation, Writing – review & editing
Affiliation Vaccine Development Unit, Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Brandi Richardson,
Roles Investigation, Writing – review & editing
Affiliation Vaccine Development Unit, Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Tarik Ouahes,
Roles Investigation, Writing – review & editing
Affiliation Vaccine Development Unit, Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Holly Torano,
Roles Investigation, Writing – review & editing
Affiliation Vaccine Development Unit, Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Bethany J. Jenkins,
Roles Investigation, Writing – review & editing
Affiliation Pathogenesis and Immunity Section, Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Thayne H. Dickey,
Roles Methodology, Writing – review & editing
Affiliation Host-Pathogen Interactions and Structural Vaccinology Section, Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Jillian Neal,
Roles Investigation, Writing – review & editing
Affiliation Vaccine Development Unit, Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Junhui Duan,
Roles Investigation, Writing – review & editing
Affiliation Vaccine Development Unit, Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Robert D. Morrison,
Roles Investigation, Writing – review & editing
Affiliation Vaccine Development Unit, Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Apostolos G. Gittis,
Roles Investigation
Affiliation Structural Biology Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Justin Y. A. Doritchamou,
Roles Investigation, Writing – review & editing
Affiliation Pathogenesis and Immunity Section, Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Irfan Zaidi,
Roles Project administration, Writing – review & editing
Affiliation Vaccine Development Unit, Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Lynn E. Lambert,
Roles Project administration, Supervision, Writing – review & editing
Affiliation Vaccine Development Unit, Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Patrick E. Duffy,
Roles Project administration, Supervision, Writing – review & editing
Affiliations Vaccine Development Unit, Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America, Pathogenesis and Immunity Section, Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Niraj H. Tolia
Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
* E-mail: niraj.tolia@nih.gov
Affiliation Host-Pathogen Interactions and Structural Vaccinology Section, Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Structure-guided design of VAR2CSA-based immunogens and a cocktail strategy for a placental malaria vaccine
- Rui Ma,
- Nichole D. Salinas,
- Sachy Orr-Gonzalez,
- Brandi Richardson,
- Tarik Ouahes,
- Holly Torano,
- Bethany J. Jenkins,
- Thayne H. Dickey,
- Jillian Neal,
- Junhui Duan
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- Published: March 4, 2024
- https://doi.org/10.1371/journal.ppat.1011879