CNP blocks mitochondrial depolarization and inhibits SARS-CoV-2 replication in vitro and in vivo

James Logue; Victoria M. Melville; Jeremy Ardanuy; Matthew B. Frieman

doi:10.1371/journal.ppat.1011870

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Open Access

Peer-reviewed

Research Article

CNP blocks mitochondrial depolarization and inhibits SARS-CoV-2 replication in vitro and in vivo

James Logue,

Roles Conceptualization, Investigation, Writing – original draft, Writing – review & editing

Affiliations The Department of Microbiology and Immunology, The University of Maryland School of Medicine, Baltimore, Maryland, United States of America, Center for Pathogen Research, The University of Maryland School of Medicine, Baltimore, Maryland, United States of America
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Victoria M. Melville,

Roles Investigation, Writing – original draft, Writing – review & editing

Affiliations The Department of Microbiology and Immunology, The University of Maryland School of Medicine, Baltimore, Maryland, United States of America, Center for Pathogen Research, The University of Maryland School of Medicine, Baltimore, Maryland, United States of America
⨯
Jeremy Ardanuy,

Roles Investigation, Writing – original draft, Writing – review & editing

Affiliations The Department of Microbiology and Immunology, The University of Maryland School of Medicine, Baltimore, Maryland, United States of America, Center for Pathogen Research, The University of Maryland School of Medicine, Baltimore, Maryland, United States of America
⨯
Matthew B. Frieman

Roles Conceptualization, Investigation, Writing – review & editing

* E-mail: mfrieman@som.umaryland.edu

Affiliations The Department of Microbiology and Immunology, The University of Maryland School of Medicine, Baltimore, Maryland, United States of America, Center for Pathogen Research, The University of Maryland School of Medicine, Baltimore, Maryland, United States of America

https://orcid.org/0000-0003-0107-0775

⨯

CNP blocks mitochondrial depolarization and inhibits SARS-CoV-2 replication in vitro and in vivo

James Logue,
Victoria M. Melville,
Jeremy Ardanuy,
Matthew B. Frieman

Published: December 20, 2023
https://doi.org/10.1371/journal.ppat.1011870

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SARS CoV 2
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Mitochondria
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Virions
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Viral replication
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COVID 19
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Depolarization
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Reactive oxygen species
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Cell staining
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