Convergent evolution of SARS-CoV-2 XBB lineages on receptor-binding domain 455–456 synergistically enhances antibody evasion and ACE2 binding

Fanchong Jian; Leilei Feng; Sijie Yang; Yuanling Yu; Lei Wang; Weiliang Song; Ayijiang Yisimayi; Xiaosu Chen; Yanli Xu; Peng Wang; Lingling Yu; Jing Wang; Lu Liu; Xiao Niu; Jing Wang; Tianhe Xiao; Ran An; Yao Wang; Qingqing Gu; Fei Shao; Ronghua Jin; Zhongyang Shen; Youchun Wang; Xiangxi Wang; Yunlong Cao

doi:10.1371/journal.ppat.1011868

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Open Access

Peer-reviewed

Research Article

Convergent evolution of SARS-CoV-2 XBB lineages on receptor-binding domain 455–456 synergistically enhances antibody evasion and ACE2 binding

Fanchong Jian ,

Contributed equally to this work with: Fanchong Jian, Leilei Feng, Sijie Yang, Yuanling Yu

Roles Data curation, Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, People’s Republic of China, Changping Laboratory, Beijing, People’s Republic of China, College of Chemistry and Molecular Engineering, Peking University, Beijing, People’s Republic of China

https://orcid.org/0000-0001-8703-3507

⨯
Leilei Feng ,

Contributed equally to this work with: Fanchong Jian, Leilei Feng, Sijie Yang, Yuanling Yu

Roles Data curation, Formal analysis, Investigation, Visualization

Affiliations CAS Key Laboratory of Infection and Immunity, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, People’s Republic of China, University of Chinese Academy of Sciences, Beijing, People’s Republic of China
⨯
Sijie Yang ,

Contributed equally to this work with: Fanchong Jian, Leilei Feng, Sijie Yang, Yuanling Yu

Roles Data curation, Visualization

Affiliations Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, People’s Republic of China, Peking-Tsinghua Center for Life Sciences, Tsinghua University, Beijing, People’s Republic of China
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Yuanling Yu ,

Contributed equally to this work with: Fanchong Jian, Leilei Feng, Sijie Yang, Yuanling Yu

Roles Investigation, Methodology, Resources

Affiliation Changping Laboratory, Beijing, People’s Republic of China
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Lei Wang,

Roles Investigation

Affiliations CAS Key Laboratory of Infection and Immunity, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, People’s Republic of China, University of Chinese Academy of Sciences, Beijing, People’s Republic of China
⨯
Weiliang Song,

Roles Formal analysis, Visualization

Affiliations Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, People’s Republic of China, Changping Laboratory, Beijing, People’s Republic of China, School of Life Sciences, Peking University, Beijing, People’s Republic of China
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Ayijiang Yisimayi,

Roles Investigation

Affiliations Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, People’s Republic of China, Changping Laboratory, Beijing, People’s Republic of China, School of Life Sciences, Peking University, Beijing, People’s Republic of China
⨯
Xiaosu Chen,

Roles Resources

Affiliation Institute for Immunology, College of Life Sciences, Nankai University, Tianjin, People’s Republic of China
⨯
Yanli Xu,

Roles Resources

Affiliation Beijing Ditan Hospital, Capital Medical University, Beijing, People’s Republic of China
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Peng Wang,

Roles Investigation

Affiliation Changping Laboratory, Beijing, People’s Republic of China
⨯
Lingling Yu,

Roles Investigation

Affiliation Changping Laboratory, Beijing, People’s Republic of China
⨯
Jing Wang,

Roles Investigation

Affiliation Changping Laboratory, Beijing, People’s Republic of China
⨯
Lu Liu,

Roles Investigation

Affiliation Changping Laboratory, Beijing, People’s Republic of China
⨯
Xiao Niu,

Roles Investigation

Affiliations Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, People’s Republic of China, College of Chemistry and Molecular Engineering, Peking University, Beijing, People’s Republic of China
⨯
Jing Wang,

Roles Investigation

Affiliations Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, People’s Republic of China, Changping Laboratory, Beijing, People’s Republic of China, School of Life Sciences, Peking University, Beijing, People’s Republic of China
⨯
Tianhe Xiao,

Roles Investigation

Affiliations Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, People’s Republic of China, Joint Graduate Program of Peking-Tsinghua-NIBS, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, People’s Republic of China
⨯
Ran An,

Roles Investigation

Affiliation Changping Laboratory, Beijing, People’s Republic of China
⨯
Yao Wang,

Roles Investigation

Affiliation Changping Laboratory, Beijing, People’s Republic of China
⨯
Qingqing Gu,

Roles Writing – review & editing

Affiliation Changping Laboratory, Beijing, People’s Republic of China
⨯
Fei Shao,

Roles Project administration

Affiliation Changping Laboratory, Beijing, People’s Republic of China
⨯
Ronghua Jin,

Roles Resources

Affiliation Beijing Ditan Hospital, Capital Medical University, Beijing, People’s Republic of China
⨯
Zhongyang Shen,

Roles Resources

Affiliation Organ Transplant Center, NHC Key Laboratory for Critical Care Medicine, Tianjin First Central Hospital, Nankai University, Tianjin, People’s Republic of China
⨯
Youchun Wang,

Roles Resources

Affiliations Changping Laboratory, Beijing, People’s Republic of China, Institute of Medical Biology, Chinese Academy of Medical Science & Peking Union Medical College, Kunming, People’s Republic of China
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Xiangxi Wang ,

Roles Supervision

* E-mail: xiangxi@ibp.ac.cn (XW); yunlongcao@pku.edu.cn (YC)

Affiliations CAS Key Laboratory of Infection and Immunity, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, People’s Republic of China, University of Chinese Academy of Sciences, Beijing, People’s Republic of China
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[ ... ],
Yunlong Cao

Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – review & editing

* E-mail: xiangxi@ibp.ac.cn (XW); yunlongcao@pku.edu.cn (YC)

Affiliations Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, People’s Republic of China, Changping Laboratory, Beijing, People’s Republic of China

https://orcid.org/0000-0001-5918-1078

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Convergent evolution of SARS-CoV-2 XBB lineages on receptor-binding domain 455–456 synergistically enhances antibody evasion and ACE2 binding

Fanchong Jian,
Leilei Feng,
Sijie Yang,
Yuanling Yu,
Lei Wang,
Weiliang Song,
Ayijiang Yisimayi,
Xiaosu Chen,
Yanli Xu,
Peng Wang

Published: December 20, 2023
https://doi.org/10.1371/journal.ppat.1011868

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