The V2 domain of HIV gp120 mimics an interaction between CD4 and integrin ⍺4β7

Donald Van Ryk; Sinmanus Vimonpatranon; Joe Hiatt; Sundar Ganesan; Nathalie Chen; Jordan McMurry; Saadiq Garba; Susie Min; Livia R. Goes; Alexandre Girard; Jason Yolitz; Isabella Licavoli; Danlan Wei; Dawei Huang; Marcelo A. Soares; Elena Martinelli; Claudia Cicala; James Arthos

doi:10.1371/journal.ppat.1011860

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Peer-reviewed

Research Article

The V2 domain of HIV gp120 mimics an interaction between CD4 and integrin ⍺₄β₇

Donald Van Ryk ,

Contributed equally to this work with: Donald Van Ryk, Sinmanus Vimonpatranon

Roles Conceptualization, Investigation, Methodology, Validation, Writing – review & editing

Affiliation Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, United States of America
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Sinmanus Vimonpatranon ,

Contributed equally to this work with: Donald Van Ryk, Sinmanus Vimonpatranon

Roles Conceptualization, Investigation, Methodology, Supervision, Visualization, Writing – review & editing

Affiliations Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, United States of America, Department of Retrovirology, Armed Forces Research Institute of Medical Sciences–United States Component, Bangkok, Thailand
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Joe Hiatt,

Roles Investigation, Methodology

Affiliation Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, United States of America
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Sundar Ganesan,

Roles Conceptualization, Investigation, Visualization, Writing – review & editing

Affiliation Biological Imaging Section, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, United States of America
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Nathalie Chen,

Roles Investigation

Affiliation Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, United States of America
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Jordan McMurry,

Roles Investigation

Affiliation Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, United States of America
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Saadiq Garba,

Roles Investigation

Affiliation Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, United States of America
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Susie Min,

Roles Investigation

Affiliation Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, United States of America
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Livia R. Goes,

Roles Investigation

Affiliations Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, United States of America, Oncovirology Program, Instituto Nacional de Câncer, Rio de Janeiro, Rio de Janeiro, Brazil
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Alexandre Girard,

Roles Investigation, Methodology, Visualization

Affiliation Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, United States of America
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Jason Yolitz,

Roles Investigation

Affiliation Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, United States of America
⨯
Isabella Licavoli,

Roles Investigation

Affiliation Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, United States of America
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Danlan Wei,

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, United States of America
⨯
Dawei Huang,

Roles Formal analysis, Methodology, Writing – review & editing

Affiliation Lymphoid Malignancies Branch, National Cancer Institute, Bethesda, Maryland, United States of America
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Marcelo A. Soares,

Roles Conceptualization, Supervision

Affiliations Oncovirology Program, Instituto Nacional de Câncer, Rio de Janeiro, Rio de Janeiro, Brazil, Department of Genetics, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
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Elena Martinelli,

Roles Conceptualization, Writing – review & editing

Affiliation Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
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Claudia Cicala,

Roles Conceptualization, Supervision, Validation, Writing – review & editing

Affiliation Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, United States of America
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[ ... ],
James Arthos

Roles Conceptualization, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: jarthos@niaid.nih.gov

Affiliation Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, United States of America

https://orcid.org/0000-0002-6767-4267

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The V2 domain of HIV gp120 mimics an interaction between CD4 and integrin ⍺₄β₇

Donald Van Ryk,
Sinmanus Vimonpatranon,
Joe Hiatt,
Sundar Ganesan,
Nathalie Chen,
Jordan McMurry,
Saadiq Garba,
Susie Min,
Livia R. Goes,
Alexandre Girard

Published: December 8, 2023
https://doi.org/10.1371/journal.ppat.1011860

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HIV
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T helper cells
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Integrins
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Cell binding
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Sequence alignment
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