Regulation of Ebola GP conformation and membrane binding by the chemical environment of the late endosome

Aastha Jain; Ramesh Govindan; Alex R. Berkman; Jeremy Luban; Marco A. Díaz-Salinas; Natasha D. Durham; James B. Munro

doi:10.1371/journal.ppat.1011848

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Open Access

Peer-reviewed

Research Article

Regulation of Ebola GP conformation and membrane binding by the chemical environment of the late endosome

Aastha Jain,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Microbiology and Physiological Systems, UMass Chan Medical School, Worcester, Massachusetts, United States of America
⨯
Ramesh Govindan,

Roles Conceptualization, Investigation, Methodology

Affiliations Department of Microbiology and Physiological Systems, UMass Chan Medical School, Worcester, Massachusetts, United States of America, Medical Scientist Training Program, Tufts University School of Medicine, Boston, Massachusetts, United States of America
⨯
Alex R. Berkman,

Roles Formal analysis, Investigation

Affiliation Department of Microbiology and Physiological Systems, UMass Chan Medical School, Worcester, Massachusetts, United States of America
⨯
Jeremy Luban,

Roles Funding acquisition, Writing – review & editing

Affiliations Program in Molecular Medicine, UMass Chan Medical School, Worcester, Massachusetts, United States of America, Department of Biochemistry and Molecular Biotechnology, UMass Chan Medical School, Worcester, Massachusetts, United States of America
⨯
Marco A. Díaz-Salinas,

Roles Resources, Writing – review & editing

Affiliation Department of Microbiology and Physiological Systems, UMass Chan Medical School, Worcester, Massachusetts, United States of America
⨯
Natasha D. Durham,

Roles Writing – review & editing

Affiliation Department of Microbiology and Physiological Systems, UMass Chan Medical School, Worcester, Massachusetts, United States of America
⨯
James B. Munro

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Software, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: james.munro@umassmed.edu

Affiliations Department of Microbiology and Physiological Systems, UMass Chan Medical School, Worcester, Massachusetts, United States of America, Department of Biochemistry and Molecular Biotechnology, UMass Chan Medical School, Worcester, Massachusetts, United States of America

https://orcid.org/0000-0001-7634-4633

⨯

Regulation of Ebola GP conformation and membrane binding by the chemical environment of the late endosome

Aastha Jain,
Ramesh Govindan,
Alex R. Berkman,
Jeremy Luban,
Marco A. Díaz-Salinas,
Natasha D. Durham,
James B. Munro

Published: December 6, 2023
https://doi.org/10.1371/journal.ppat.1011848

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Membrane fusion
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Fluorescence resonance energy transfer
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Liposomes
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Lipids
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Ebola virus
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Endosomes
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