Experimental infection of pigs and ferrets with “pre-pandemic,” human-adapted, and swine-adapted variants of the H1N1pdm09 influenza A virus reveals significant differences in viral dynamics and pathological manifestations

• Charlotte Kristensen ,

  Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: chark@sund.ku.dk

  Affiliation Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg C, Denmark

  https://orcid.org/0009-0006-7912-172X

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• Helena A. Laybourn,

  Roles Formal analysis, Investigation, Visualization, Writing – review & editing

  Affiliation Department of Biotechnology and Biomedicine, Technical University of Denmark, Kgs. Lyngby, Denmark

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• Jeri-Carol Crumpton,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN, United States of America

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• Karen Martiny,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg C, Denmark

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• Ashley Webb,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN, United States of America

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• Pia Ryt-Hansen,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg C, Denmark

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• Ramona Trebbien,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliation Department of Virus and Microbiological Special Diagnostics, Statens Serum Institut, Copenhagen S, Denmark

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• Henrik E. Jensen,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg C, Denmark

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• Jakob N. Nissen,

  Roles Conceptualization, Methodology, Writing – review & editing

  Current address: Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen N, Denmark

  Affiliation Department of Virus and Microbiological Special Diagnostics, Statens Serum Institut, Copenhagen S, Denmark

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• Kerstin Skovgaard,

  Roles Conceptualization, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Biotechnology and Biomedicine, Technical University of Denmark, Kgs. Lyngby, Denmark

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• Richard J. Webby,

  Roles Conceptualization, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN, United States of America

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• Lars E. Larsen

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – review & editing

  Affiliation Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg C, Denmark

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