Positive selection analyses identify a single WWE domain residue that shapes ZAP into a more potent restriction factor against alphaviruses

• Serina Huang,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, California, United States of America

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• Juliana Girdner,

  Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Chemistry and Biochemistry, University of California, Los Angeles, California, United States of America, Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, California, United States of America

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• LeAnn P. Nguyen,

  Roles Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliations Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, California, United States of America, Molecular Biology Institute, University of California, Los Angeles, California, United States of America

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• Carina Sandoval,

  Roles Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliation Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, California, United States of America

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• Oliver I. Fregoso,

  Roles Resources, Supervision, Writing – review & editing

  Affiliations Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, California, United States of America, Molecular Biology Institute, University of California, Los Angeles, California, United States of America

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• David Enard,

  Roles Resources, Software, Writing – review & editing

  Affiliation Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona, United States of America

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• Melody M. H. Li

  Roles Conceptualization, Data curation, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: manhingli@mednet.ucla.edu

  Affiliations Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, California, United States of America, Molecular Biology Institute, University of California, Los Angeles, California, United States of America, AIDS Institute, David Geffen School of Medicine, University of California, Los Angeles, California, United States of America

  https://orcid.org/0000-0002-6905-7940

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