Potent antibody-dependent cellular cytotoxicity of a V2-specific antibody is not sufficient for protection of macaques against SIV challenge

• Michael W. Grunst ,

  Contributed equally to this work with: Michael W. Grunst, Hwi Min Gil

  Roles Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

  Affiliation Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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• Hwi Min Gil ,

  Contributed equally to this work with: Michael W. Grunst, Hwi Min Gil

  Roles Formal analysis, Investigation, Visualization, Writing – review & editing

  Affiliation Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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• Andres G. Grandea III,

  Roles Investigation, Supervision, Writing – review & editing

  Affiliations Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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• Brian J. Snow,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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• Raiees Andrabi,

  Roles Investigation, Writing – review & editing

  Current Address: Present address: Department of Medicine, University of Pennsylvannia, Philadelphia, Pennyslvania, United States of America

  Affiliations Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America, International AIDS Vaccine Initiative Neutralizing Antibody Center, the Collaboration for AIDS Vaccine Discovery (CAVD) and Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America

  ⨯
• Rebecca Nedellec,

  Roles Investigation

  Affiliations Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America, International AIDS Vaccine Initiative Neutralizing Antibody Center, the Collaboration for AIDS Vaccine Discovery (CAVD) and Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America

  ⨯
• Iszac Burton,

  Roles Investigation

  Affiliations Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America, International AIDS Vaccine Initiative Neutralizing Antibody Center, the Collaboration for AIDS Vaccine Discovery (CAVD) and Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America

  ⨯
• Natasha M. Clark,

  Roles Investigation

  Affiliation Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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• Sanath Kumar Janaka,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

  ⨯
• Nida K. Keles,

  Roles Investigation

  Affiliation Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

  ⨯
• Ryan V. Moriarty,

  Roles Investigation

  Affiliations Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

  ⨯
• Andrea M. Weiler,

  Roles Investigation, Resources

  Affiliation Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

  ⨯
• Saverio Capuano III,

  Roles Investigation, Writing – review & editing

  Affiliation Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

  ⨯
• Christine M. Fennessey,

  Roles Investigation

  Affiliation AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America

  ⨯
• Thomas C. Friedrich,

  Roles Resources, Writing – review & editing

  Affiliations Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

  ⨯
• Shelby L. O’Connor,

  Roles Formal analysis, Investigation, Resources, Writing – review & editing

  Affiliations Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

  ⨯
• David H. O’Connor,

  Roles Resources, Writing – review & editing

  Affiliations Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

  ⨯
• Aimee T. Broman,

  Roles Formal analysis

  Affiliation Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

  ⨯
• Brandon F. Keele,

  Roles Data curation, Supervision, Writing – review & editing

  Affiliation AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America

  ⨯
• Jeffrey D. Lifson,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America

  ⨯
• Lars Hangartner,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliations Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America, International AIDS Vaccine Initiative Neutralizing Antibody Center, the Collaboration for AIDS Vaccine Discovery (CAVD) and Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America

  ⨯
• Dennis R. Burton,

  Roles Resources, Supervision, Writing – review & editing

  Affiliations Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America, International AIDS Vaccine Initiative Neutralizing Antibody Center, the Collaboration for AIDS Vaccine Discovery (CAVD) and Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America, Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts, United States of America

  ⨯
•  [ ... ],
• David T. Evans

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft

  * E-mail: dtevans2@wisc.edu

  Affiliations Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

  https://orcid.org/0000-0003-2498-6292

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