NSUN2-mediated m5C modification of HBV RNA positively regulates HBV replication

Jiangpeng Feng; Tianmo Xu; Miao He; Jiali Li; Peipei Yao; Chengbao Ma; Shimin Yang; Zaichao Xu; Kun Yan; Xianying Chen; Hongyun Wang; Jiejie Liu; Cong Zeng; Yuchen Xia; Huan Yan; Li Zhou; Yu Chen

doi:10.1371/journal.ppat.1011808

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Open Access

Peer-reviewed

Research Article

NSUN2-mediated m⁵C modification of HBV RNA positively regulates HBV replication

Jiangpeng Feng ,

Contributed equally to this work with: Jiangpeng Feng, Tianmo Xu

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Writing – original draft

Affiliation State Key Laboratory of Virology, RNA Institute, College of Life Sciences and Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China
⨯
Tianmo Xu ,

Contributed equally to this work with: Jiangpeng Feng, Tianmo Xu

Roles Data curation, Formal analysis, Writing – original draft

Affiliations State Key Laboratory of Virology, RNA Institute, College of Life Sciences and Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China, Animal Bio-safety Level III Laboratory/Institute for Vaccine Research, Wuhan University School of Medicine, Wuhan, China
⨯
Miao He,

Roles Conceptualization, Data curation, Formal analysis

Affiliations State Key Laboratory of Virology, RNA Institute, College of Life Sciences and Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China, School of Medicine, Sun Yat-sen University, Guangzhou, China
⨯
Jiali Li,

Roles Data curation, Formal analysis

Affiliation State Key Laboratory of Virology, RNA Institute, College of Life Sciences and Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China
⨯
Peipei Yao,

Roles Data curation, Formal analysis

Affiliations Animal Bio-safety Level III Laboratory/Institute for Vaccine Research, Wuhan University School of Medicine, Wuhan, China, Wuhan University Taikang Medical School (School of Basic Medical Sciences), Wuhan, China
⨯
Chengbao Ma,

Roles Methodology, Resources

Affiliation State Key Laboratory of Virology, RNA Institute, College of Life Sciences and Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China
⨯
Shimin Yang,

Roles Methodology, Resources, Software

Affiliation State Key Laboratory of Virology, RNA Institute, College of Life Sciences and Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China
⨯
Zaichao Xu,

Roles Methodology, Resources

Affiliation Wuhan University Taikang Medical School (School of Basic Medical Sciences), Wuhan, China
⨯
Kun Yan,

Roles Conceptualization, Methodology

Affiliation State Key Laboratory of Virology, RNA Institute, College of Life Sciences and Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China
⨯
Xianying Chen,

Roles Conceptualization, Project administration

Affiliation State Key Laboratory of Virology, RNA Institute, College of Life Sciences and Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China
⨯
Hongyun Wang,

Roles Conceptualization, Project administration

Affiliation State Key Laboratory of Virology, RNA Institute, College of Life Sciences and Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China
⨯
Jiejie Liu,

Roles Methodology, Resources

Affiliation State Key Laboratory of Virology, RNA Institute, College of Life Sciences and Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China
⨯
Cong Zeng,

Roles Conceptualization

Affiliation School of Basic Medical Sciences, Fudan University, Shanghai, China
⨯
Yuchen Xia,

Roles Conceptualization, Resources, Writing – review & editing

Affiliation Wuhan University Taikang Medical School (School of Basic Medical Sciences), Wuhan, China
⨯
Huan Yan,

Roles Conceptualization, Methodology, Resources, Writing – review & editing

Affiliation State Key Laboratory of Virology, RNA Institute, College of Life Sciences and Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China
⨯
Li Zhou ,

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: zhouli_jerry@whu.edu.cn (LZ); chenyu@whu.edu.cn (YC)

Affiliations State Key Laboratory of Virology, RNA Institute, College of Life Sciences and Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China, Animal Bio-safety Level III Laboratory/Institute for Vaccine Research, Wuhan University School of Medicine, Wuhan, China, Wuhan University Taikang Medical School (School of Basic Medical Sciences), Wuhan, China
⨯
[ ... ],
Yu Chen

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: zhouli_jerry@whu.edu.cn (LZ); chenyu@whu.edu.cn (YC)

Affiliations State Key Laboratory of Virology, RNA Institute, College of Life Sciences and Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China, Animal Bio-safety Level III Laboratory/Institute for Vaccine Research, Wuhan University School of Medicine, Wuhan, China

https://orcid.org/0000-0003-1300-4652

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NSUN2-mediated m⁵C modification of HBV RNA positively regulates HBV replication

Jiangpeng Feng,
Tianmo Xu,
Miao He,
Jiali Li,
Peipei Yao,
Chengbao Ma,
Shimin Yang,
Zaichao Xu,
Kun Yan,
Xianying Chen

Published: December 4, 2023
https://doi.org/10.1371/journal.ppat.1011808

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