SARS-CoV-2 Nsp8 suppresses MDA5 antiviral immune responses by impairing TRIM4-mediated K63-linked polyubiquitination

Xiaolin Zhang; Ziwei Yang; Ting Pan; Qinqin Sun; Qingyang Chen; Pei-Hui Wang; Xiaojuan Li; Ersheng Kuang

doi:10.1371/journal.ppat.1011792

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Open Access

Peer-reviewed

Research Article

SARS-CoV-2 Nsp8 suppresses MDA5 antiviral immune responses by impairing TRIM4-mediated K63-linked polyubiquitination

Xiaolin Zhang ,

Contributed equally to this work with: Xiaolin Zhang, Ziwei Yang, Ting Pan

Roles Investigation, Writing – review & editing

Affiliation Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China
⨯
Ziwei Yang ,

Contributed equally to this work with: Xiaolin Zhang, Ziwei Yang, Ting Pan

Roles Investigation, Writing – original draft, Writing – review & editing

Affiliation Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China
⨯
Ting Pan ,

Contributed equally to this work with: Xiaolin Zhang, Ziwei Yang, Ting Pan

Roles Investigation, Resources

Affiliation Center for Infection and Immunity Studies, School of Medicine, Sun Yat-Sen University, Shenzhen, Guangdong, China
⨯
Qinqin Sun,

Roles Investigation

Affiliation Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China
⨯
Qingyang Chen,

Roles Investigation

Affiliation Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China
⨯
Pei-Hui Wang,

Roles Resources

Affiliation Key Laboratory for Experimental Teratology of Ministry of Education and Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
⨯
Xiaojuan Li ,

Roles Conceptualization, Funding acquisition, Investigation, Supervision

* E-mail: lixjuan3@163.com (XL); kuangersh@mail.sysu.edu.cn (EK)

Affiliation College of Clinical Medicine, Hubei University of Chinese Medicine, Wuhan, Hubei, China
⨯
Ersheng Kuang

Roles Conceptualization, Funding acquisition, Investigation, Supervision, Writing – original draft, Writing – review & editing

* E-mail: lixjuan3@163.com (XL); kuangersh@mail.sysu.edu.cn (EK)

Affiliations Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China, Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education, Guangzhou, Guangdong, China

https://orcid.org/0000-0002-4976-3311

⨯

SARS-CoV-2 Nsp8 suppresses MDA5 antiviral immune responses by impairing TRIM4-mediated K63-linked polyubiquitination

Xiaolin Zhang,
Ziwei Yang,
Ting Pan,
Qinqin Sun,
Qingyang Chen,
Pei-Hui Wang,
Xiaojuan Li,
Ersheng Kuang

Published: November 13, 2023
https://doi.org/10.1371/journal.ppat.1011792

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