Antibody-mediated spike activation promotes cell-cell transmission of SARS-CoV-2

• Shi Yu ,

  Contributed equally to this work with: Shi Yu, Xu Zheng, Yanqiu Zhou

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Current address: Guangzhou National Laboratory, Department of Basic Research, Guangzhou International Bio-Island, Guangzhou, China.

  Affiliation The Center for Microbes, Development and Health, CAS Key Laboratory of Molecular Virology & Immunology, Shanghai Institute of Immunity and Infection, University of Chinese Academy of Sciences, Shanghai, China

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• Xu Zheng ,

  Contributed equally to this work with: Shi Yu, Xu Zheng, Yanqiu Zhou

  Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Validation, Visualization, Writing – review & editing

  Affiliation The Center for Microbes, Development and Health, CAS Key Laboratory of Molecular Virology & Immunology, Shanghai Institute of Immunity and Infection, University of Chinese Academy of Sciences, Shanghai, China

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• Yanqiu Zhou ,

  Contributed equally to this work with: Shi Yu, Xu Zheng, Yanqiu Zhou

  Roles Investigation, Resources

  Affiliation Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

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• Yuhui Gao,

  Roles Formal analysis, Investigation

  Affiliation The Center for Microbes, Development and Health, CAS Key Laboratory of Molecular Virology & Immunology, Shanghai Institute of Immunity and Infection, University of Chinese Academy of Sciences, Shanghai, China

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• Bingjie Zhou,

  Roles Resources

  Affiliation The Center for Microbes, Development and Health, CAS Key Laboratory of Molecular Virology & Immunology, Shanghai Institute of Immunity and Infection, University of Chinese Academy of Sciences, Shanghai, China

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• Yapei Zhao,

  Roles Resources

  Affiliation The Center for Microbes, Development and Health, CAS Key Laboratory of Molecular Virology & Immunology, Shanghai Institute of Immunity and Infection, University of Chinese Academy of Sciences, Shanghai, China

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• Tingting Li,

  Roles Resources

  Affiliation State Key Laboratory of Molecular Biology, State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS), Shanghai, China

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• Yunyi Li,

  Roles Investigation, Resources

  Affiliation Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

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• Jiabin Mou,

  Roles Investigation, Resources

  Affiliation Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

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• Xiaoxian Cui,

  Roles Investigation, Resources

  Affiliation Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

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• Yuying Yang,

  Roles Investigation, Resources

  Affiliation Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

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• Dianfan Li,

  Roles Funding acquisition, Resources

  Affiliation State Key Laboratory of Molecular Biology, State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS), Shanghai, China

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• Min Chen ,

  Roles Resources

  * E-mail: chenmin@scdc.sh.cn (MC); dimitri.lavillette@ip-korea.org (DL); gxmeng@ips.ac.cn (GM)

  Affiliation Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

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• Dimitri Lavillette ,

  Roles Funding acquisition, Methodology, Resources, Supervision

  * E-mail: chenmin@scdc.sh.cn (MC); dimitri.lavillette@ip-korea.org (DL); gxmeng@ips.ac.cn (GM)

  Affiliations The Center for Microbes, Development and Health, CAS Key Laboratory of Molecular Virology & Immunology, Shanghai Institute of Immunity and Infection, University of Chinese Academy of Sciences, Shanghai, China, Pasteurien College, Soochow University, Suzhou, Jiangsu, China, Applied Molecular Virology Laboratory, Discovery Biology Department, Institut Pasteur Korea, Gyeonggi-do, South Korea

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• Guangxun Meng

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: chenmin@scdc.sh.cn (MC); dimitri.lavillette@ip-korea.org (DL); gxmeng@ips.ac.cn (GM)

  Affiliations The Center for Microbes, Development and Health, CAS Key Laboratory of Molecular Virology & Immunology, Shanghai Institute of Immunity and Infection, University of Chinese Academy of Sciences, Shanghai, China, Pasteurien College, Soochow University, Suzhou, Jiangsu, China, Nanjing Advanced Academy of Life and Health, Nanjing, Jiangsu, China

  https://orcid.org/0000-0003-4634-4661

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