A small molecule exerts selective antiviral activity by targeting the human cytomegalovirus nuclear egress complex

• Han Chen ,

  Contributed equally to this work with: Han Chen, Ming F. Lye

  Roles Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Ming F. Lye ,

  Contributed equally to this work with: Han Chen, Ming F. Lye

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, United States of America

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• Christoph Gorgulla,

  Roles Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Physics, Harvard University, Cambridge, Massachusetts, United States of America, Department of Structural Biology, St. Jude’s Children’s Research Hospital, Memphis Tennessee United States of America

  ⨯
• Scott B. Ficarro,

  Roles Investigation, Writing – original draft, Writing – review & editing

  Affiliations Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Blais Proteomics Center, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Center for Emergent Drug Targets, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Gregory D. Cuny,

  Roles Conceptualization, Project administration, Supervision, Writing – review & editing

  Affiliation Department of Pharmacological and Pharmaceutical Sciences, University of Houston College of Pharmacy, Houston, Texas, United States of America

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• David A. Scott,

  Roles Conceptualization, Resources, Supervision, Writing – review & editing

  Affiliations Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Medicinal Chemistry Core, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

  ⨯
• Fan Wu,

  Roles Funding acquisition, Investigation, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Paul W. Rothlauf,

  Roles Funding acquisition, Investigation, Writing – review & editing

  Affiliation Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Xiaoou Wang,

  Roles Funding acquisition, Investigation, Writing – review & editing

  Affiliation Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Rosio Fernandez,

  Roles Funding acquisition, Investigation, Resources, Writing – review & editing

  Affiliation Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Jean M. Pesola,

  Roles Formal analysis, Validation, Visualization, Writing – review & editing

  Affiliation Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Sorin Draga,

  Roles Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Virtual Discovery, Inc. Chestnut Hill, Massachusetts United States of America, Non-Governmental Research Organization Biologic, Bucharest Romania

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• Jarrod A. Marto,

  Roles Funding acquisition, Resources, Supervision, Writing – review & editing

  Affiliations Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Blais Proteomics Center, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Center for Emergent Drug Targets, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• James M. Hogle,

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

  Affiliation Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Haribabu Arthanari,

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

  Affiliations Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

  ⨯
•  [ ... ],
• Donald M. Coen

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: don_coen@hms.harvard.edu

  Affiliation Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0002-2148-5671

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