Homologous Ad26.COV2.S vaccination results in reduced boosting of humoral responses in hybrid immunity, but elicits antibodies of similar magnitude regardless of prior infection

• Thandeka Moyo-Gwete ,

  Contributed equally to this work with: Thandeka Moyo-Gwete, Simone I. Richardson, Roanne Keeton

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations SA MRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa, Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa

  ⨯
• Simone I. Richardson ,

  Contributed equally to this work with: Thandeka Moyo-Gwete, Simone I. Richardson, Roanne Keeton

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations SA MRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa, Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa

  ⨯
• Roanne Keeton ,

  Contributed equally to this work with: Thandeka Moyo-Gwete, Simone I. Richardson, Roanne Keeton

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa, Division of Medical Virology, Department of Pathology; University of Cape Town; Observatory, South Africa

  ⨯
• Tandile Hermanus,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliations SA MRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa, Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa

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• Holly Spencer,

  Roles Investigation, Writing – review & editing

  Affiliations SA MRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa, Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa

  ⨯
• Nelia P. Manamela,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliations SA MRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa, Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa

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• Frances Ayres,

  Roles Investigation, Writing – review & editing

  Affiliations SA MRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa, Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa

  ⨯
• Zanele Makhado,

  Roles Investigation, Writing – review & editing

  Affiliations SA MRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa, Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa

  ⨯
• Thopisang Motlou,

  Roles Investigation, Writing – review & editing

  Affiliations SA MRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa, Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa

  ⨯
• Marius B. Tincho,

  Roles Investigation, Writing – review & editing

  Affiliations Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa, Division of Medical Virology, Department of Pathology; University of Cape Town; Observatory, South Africa

  ⨯
• Ntombi Benede,

  Roles Investigation, Writing – review & editing

  Affiliations Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa, Division of Medical Virology, Department of Pathology; University of Cape Town; Observatory, South Africa

  ⨯
• Amkele Ngomti,

  Roles Investigation, Writing – review & editing

  Affiliations Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa, Division of Medical Virology, Department of Pathology; University of Cape Town; Observatory, South Africa

  ⨯
• Richard Baguma,

  Roles Investigation, Writing – review & editing

  Affiliations Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa, Division of Medical Virology, Department of Pathology; University of Cape Town; Observatory, South Africa

  ⨯
• Masego V. Chauke,

  Roles Investigation, Writing – review & editing

  Affiliations Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa, Division of Medical Virology, Department of Pathology; University of Cape Town; Observatory, South Africa

  ⨯
• Mathilda Mennen,

  Roles Investigation, Writing – review & editing

  Affiliations Department of Medicine, University of Cape Town and Groote Schuur Hospital; Observatory, South Africa, Cape Heart Institute, Faculty of Health Sciences, University of Cape Town; Observatory, South Africa, South African Medical Research Council Extramural Unit on Intersection of Non-communicable Diseases and Infectious Diseases, University of Cape Town, Cape Town, South Africa

  ⨯
• Marguerite Adriaanse,

  Roles Investigation, Writing – review & editing

  Affiliations Department of Medicine, University of Cape Town and Groote Schuur Hospital; Observatory, South Africa, Cape Heart Institute, Faculty of Health Sciences, University of Cape Town; Observatory, South Africa, South African Medical Research Council Extramural Unit on Intersection of Non-communicable Diseases and Infectious Diseases, University of Cape Town, Cape Town, South Africa

  ⨯
• Sango Skelem,

  Roles Investigation, Writing – review & editing

  Affiliations Department of Medicine, University of Cape Town and Groote Schuur Hospital; Observatory, South Africa, Cape Heart Institute, Faculty of Health Sciences, University of Cape Town; Observatory, South Africa, South African Medical Research Council Extramural Unit on Intersection of Non-communicable Diseases and Infectious Diseases, University of Cape Town, Cape Town, South Africa

  ⨯
• Ameena Goga,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliation South African Medical Research Council, Cape Town, South Africa

  ⨯
• Nigel Garrett,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliations Centre for the AIDS Programme of Research in South Africa, Durban, South Africa, Discipline of Public Health Medicine, University of KwaZulu-Natal, Durban, South Africa

  ⨯
• Linda-Gail Bekker,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliations Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa, Desmond Tutu HIV Centre, Cape Town, South Africa

  ⨯
• Glenda Gray,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliation South African Medical Research Council, Cape Town, South Africa

  ⨯
• Ntobeko A. B. Ntusi,

  Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – review & editing

  Affiliations Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa, Department of Medicine, University of Cape Town and Groote Schuur Hospital; Observatory, South Africa, Cape Heart Institute, Faculty of Health Sciences, University of Cape Town; Observatory, South Africa, South African Medical Research Council Extramural Unit on Intersection of Non-communicable Diseases and Infectious Diseases, University of Cape Town, Cape Town, South Africa, Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory, South Africa

  ⨯
• Catherine Riou ,

  Roles Conceptualization, Data curation, Funding acquisition, Supervision, Writing – review & editing

  * E-mail: cr.riou@uct.ac.za (CR); wendy.burgers@uct.ac.za (WAB); pennym@nicd.ac.za (PLM)

  Affiliations Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa, Division of Medical Virology, Department of Pathology; University of Cape Town; Observatory, South Africa, Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory, South Africa

  ⨯
• Wendy A. Burgers ,

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Writing – original draft, Writing – review & editing

  * E-mail: cr.riou@uct.ac.za (CR); wendy.burgers@uct.ac.za (WAB); pennym@nicd.ac.za (PLM)

  Affiliations Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa, Division of Medical Virology, Department of Pathology; University of Cape Town; Observatory, South Africa, Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory, South Africa

  ⨯
•  [ ... ],
• Penny L. Moore

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: cr.riou@uct.ac.za (CR); wendy.burgers@uct.ac.za (WAB); pennym@nicd.ac.za (PLM)

  Affiliations SA MRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa, Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa, Centre for the AIDS Programme of Research in South Africa, Durban, South Africa

  https://orcid.org/0000-0001-8719-4028

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