Flavivirus genome recoding by codon optimisation confers genetically stable in vivo attenuation in both mice and mosquitoes

• Wei-Xin Chin,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology and Immunology and Infectious Diseases Translational Research Programme, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore

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• Hao Yuin Kong,

  Roles Formal analysis, Investigation

  Affiliation NUSMed Biosafety Level 3 Core Facility, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

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• Isabelle Xin Yu Zhu,

  Roles Formal analysis, Investigation

  Affiliation Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology and Immunology and Infectious Diseases Translational Research Programme, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore

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• Zi Yun Teo,

  Roles Investigation

  Affiliation Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology and Immunology and Infectious Diseases Translational Research Programme, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore

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• Regina Faruk,

  Roles Formal analysis, Investigation

  Affiliation Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology and Immunology and Infectious Diseases Translational Research Programme, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore

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• Regina Ching Hua Lee,

  Roles Investigation, Methodology

  Affiliation Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology and Immunology and Infectious Diseases Translational Research Programme, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore

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• Si Xian Ho,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology and Immunology and Infectious Diseases Translational Research Programme, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore

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• Zhen Qin Aw,

  Roles Investigation

  Affiliation NUSMed Biosafety Level 3 Core Facility, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

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• Bowen Yi,

  Roles Formal analysis, Investigation

  Affiliation NUSMed Biosafety Level 3 Core Facility, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

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• Xin Jun Hou,

  Roles Investigation

  Affiliations Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore, Singapore, Department of Biological Sciences, National University of Singapore, Singapore

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• Antson Kiat Yee Tan,

  Roles Investigation

  Affiliation Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore

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• Thinesshwary Yogarajah,

  Roles Investigation, Methodology

  Affiliation Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology and Immunology and Infectious Diseases Translational Research Programme, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore

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• Roland G. Huber,

  Roles Formal analysis, Methodology

  Affiliation Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Singapore

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• Yu Cai,

  Roles Methodology

  Affiliations Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore, Singapore, Department of Biological Sciences, National University of Singapore, Singapore

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• Yue Wan,

  Roles Methodology

  Affiliation Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore

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•  [ ... ],
• Justin Jang Hann Chu

  Roles Conceptualization, Funding acquisition, Methodology, Supervision

  * E-mail: miccjh@nus.edu.sg

  Affiliations Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology and Immunology and Infectious Diseases Translational Research Programme, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore, NUSMed Biosafety Level 3 Core Facility, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore

  https://orcid.org/0000-0002-1673-6819

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