The rotavirus VP5*/VP8* conformational transition permeabilizes membranes to Ca2+

Marilina de Sautu; Tobias Herrmann; Gustavo Scanavachi; Simon Jenni; Stephen C. Harrison

doi:10.1371/journal.ppat.1011750

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Peer-reviewed

Research Article

The rotavirus VP5/VP8 conformational transition permeabilizes membranes to Ca²⁺

Marilina de Sautu ,

Contributed equally to this work with: Marilina de Sautu, Tobias Herrmann

Roles Data curation, Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America, Laboratory of Molecular Medicine, Boston Children’s Hospital, Boston, Massachusetts, United States of America
⨯
Tobias Herrmann ,

Contributed equally to this work with: Marilina de Sautu, Tobias Herrmann

Roles Data curation, Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Gustavo Scanavachi,

Roles Data curation, Formal analysis, Software

Affiliations Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, Massachusetts, United States of America
⨯
Simon Jenni ,

Roles Data curation, Formal analysis, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: jenni@crystal.harvard.edu (SJ); harrison@crystal.harvard.edu (SH)

Affiliation Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America
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Stephen C. Harrison

Roles Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

* E-mail: jenni@crystal.harvard.edu (SJ); harrison@crystal.harvard.edu (SH)

Affiliations Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America, Laboratory of Molecular Medicine, Boston Children’s Hospital, Boston, Massachusetts, United States of America, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, United States of America

https://orcid.org/0000-0001-7215-9393

⨯

The rotavirus VP5/VP8 conformational transition permeabilizes membranes to Ca²⁺

Marilina de Sautu,
Tobias Herrmann,
Gustavo Scanavachi,
Simon Jenni,
Stephen C. Harrison

Published: April 4, 2024
https://doi.org/10.1371/journal.ppat.1011750

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