Inflammasome-triggered IL-18 controls skin inflammation in the progression of Buruli ulcer

Toshihiko Suzuki; Kotchakorn Boonyaleka; Tokuju Okano; Tamako Iida; Mitsunori Yoshida; Hanako Fukano; Yoshihiko Hoshino; Yoichiro Iwakura; Anthony S. Ablordey; Hiroshi Ashida

doi:10.1371/journal.ppat.1011747

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Open Access

Peer-reviewed

Research Article

Inflammasome-triggered IL-18 controls skin inflammation in the progression of Buruli ulcer

Toshihiko Suzuki ,

Roles Conceptualization, Investigation, Writing – original draft

* E-mail: suzuki.bact@tmd.ac.jp

Affiliation Department of Bacterial Pathogenesis, Infection and Host Response, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan

https://orcid.org/0000-0003-3853-0106

⨯
Kotchakorn Boonyaleka,

Roles Formal analysis, Investigation, Resources

Affiliation Department of Bacterial Pathogenesis, Infection and Host Response, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan
⨯
Tokuju Okano,

Roles Formal analysis, Investigation, Resources

Affiliation Department of Bacterial Pathogenesis, Infection and Host Response, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan
⨯
Tamako Iida,

Roles Resources

Affiliation Department of Bacterial Pathogenesis, Infection and Host Response, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan
⨯
Mitsunori Yoshida,

Roles Resources

Affiliation Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
⨯
Hanako Fukano,

Roles Resources

Affiliation Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
⨯
Yoshihiko Hoshino,

Roles Resources

Affiliation Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
⨯
Yoichiro Iwakura,

Roles Resources

Affiliation Research Institute for Biomedical Sciences, Tokyo University of Science, Noda, Chiba, Japan
⨯
Anthony S. Ablordey,

Roles Resources

Affiliation Department of Bacteriology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana
⨯
Hiroshi Ashida

Roles Formal analysis

Affiliation Department of Bacterial Pathogenesis, Infection and Host Response, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan
⨯

Inflammasome-triggered IL-18 controls skin inflammation in the progression of Buruli ulcer

Toshihiko Suzuki,
Kotchakorn Boonyaleka,
Tokuju Okano,
Tamako Iida,
Mitsunori Yoshida,
Hanako Fukano,
Yoshihiko Hoshino,
Yoichiro Iwakura,
Anthony S. Ablordey,
Hiroshi Ashida

Published: November 1, 2023
https://doi.org/10.1371/journal.ppat.1011747

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Mycobacterium ulcerans
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Macrophages
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Inflammasomes
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Skin infections
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Buruli ulcer
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