Tyrosine phosphorylation of IRF3 by BLK facilitates its sufficient activation and innate antiviral response

Wei-Wei Li; Xu-Xu Fan; Zi-Xiang Zhu; Xue-Jing Cao; Zhao-Yu Zhu; Dan-Shi Pei; Yi-Zhuo Wang; Ji-Yan Zhang; Yan-Yi Wang; Hai-Xue Zheng

doi:10.1371/journal.ppat.1011742

Loading metrics

Open Access

Peer-reviewed

Research Article

Tyrosine phosphorylation of IRF3 by BLK facilitates its sufficient activation and innate antiviral response

Wei-Wei Li ,

Contributed equally to this work with: Wei-Wei Li, Xu-Xu Fan

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
⨯
Xu-Xu Fan ,

Contributed equally to this work with: Wei-Wei Li, Xu-Xu Fan

Roles Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
⨯
Zi-Xiang Zhu,

Roles Investigation, Validation

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
⨯
Xue-Jing Cao,

Roles Investigation

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
⨯
Zhao-Yu Zhu,

Roles Investigation

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
⨯
Dan-Shi Pei,

Roles Investigation

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
⨯
Yi-Zhuo Wang,

Roles Investigation

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
⨯
Ji-Yan Zhang,

Roles Investigation

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
⨯
Yan-Yi Wang ,

Roles Conceptualization, Formal analysis, Methodology, Supervision, Writing – original draft, Writing – review & editing

* E-mail: wangyy@wh.iov.cn (Y-YW); haixuezheng@163.com (H-XZ)

Affiliation Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China
⨯
Hai-Xue Zheng

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: wangyy@wh.iov.cn (Y-YW); haixuezheng@163.com (H-XZ)

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China

https://orcid.org/0000-0002-1644-2300

⨯

Tyrosine phosphorylation of IRF3 by BLK facilitates its sufficient activation and innate antiviral response

Wei-Wei Li,
Xu-Xu Fan,
Zi-Xiang Zhu,
Xue-Jing Cao,
Zhao-Yu Zhu,
Dan-Shi Pei,
Yi-Zhuo Wang,
Ji-Yan Zhang,
Yan-Yi Wang,
Hai-Xue Zheng

Published: October 23, 2023
https://doi.org/10.1371/journal.ppat.1011742

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Phosphorylation
Is the Subject Area "Phosphorylation" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.
DNA transcription
Is the Subject Area "DNA transcription" applicable to this article?

Thanks for your feedback.
Tyrosine
Is the Subject Area "Tyrosine" applicable to this article?

Thanks for your feedback.
Cancers and neoplasms
Is the Subject Area "Cancers and neoplasms" applicable to this article?

Thanks for your feedback.
Immunoblot analysis
Is the Subject Area "Immunoblot analysis" applicable to this article?

Thanks for your feedback.
Antiviral immune response
Is the Subject Area "Antiviral immune response" applicable to this article?

Thanks for your feedback.
Dimerization
Is the Subject Area "Dimerization" applicable to this article?

Thanks for your feedback.