Serpin-1a and serpin-6 regulate the Toll pathway immune homeostasis by synergistically inhibiting the Spätzle-processing enzyme CLIP2 in silkworm, Bombyx mori

Huawei Liu; Jiahui Xu; Luoling Wang; Pengchao Guo; Zhangchen Tang; Xiaotong Sun; Xin Tang; Wei Wang; Lingyan Wang; Yang Cao; Qingyou Xia; Ping Zhao

doi:10.1371/journal.ppat.1011740

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Open Access

Peer-reviewed

Research Article

Serpin-1a and serpin-6 regulate the Toll pathway immune homeostasis by synergistically inhibiting the Spätzle-processing enzyme CLIP2 in silkworm, Bombyx mori

Huawei Liu ,

Contributed equally to this work with: Huawei Liu, Jiahui Xu

Roles Data curation, Investigation, Methodology, Visualization, Writing – original draft

Affiliations Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Biological Science Research Center, Southwest University, Chongqing, China, Key Laboratory for Germplasm Creation in Upper Reaches of the Yangtze River, Ministry of Agriculture and Rural Affairs, Chongqing, China
⨯
Jiahui Xu ,

Contributed equally to this work with: Huawei Liu, Jiahui Xu

Roles Data curation, Investigation, Writing – original draft

Affiliation Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Biological Science Research Center, Southwest University, Chongqing, China
⨯
Luoling Wang,

Roles Investigation, Visualization

Affiliation Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Biological Science Research Center, Southwest University, Chongqing, China
⨯
Pengchao Guo,

Roles Methodology

Affiliations Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Biological Science Research Center, Southwest University, Chongqing, China, Key Laboratory for Germplasm Creation in Upper Reaches of the Yangtze River, Ministry of Agriculture and Rural Affairs, Chongqing, China
⨯
Zhangchen Tang,

Roles Investigation

Affiliation Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Biological Science Research Center, Southwest University, Chongqing, China
⨯
Xiaotong Sun,

Roles Investigation

Affiliation Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Biological Science Research Center, Southwest University, Chongqing, China
⨯
Xin Tang,

Roles Methodology

Affiliation Chongqing Key Laboratory of Chinese Medicine & Health Science, Chongqing Academy of Chinese Materia Medica, Chongqing College of Traditional Chinese Medicine, Chongqing, China
⨯
Wei Wang,

Roles Data curation

Affiliations Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Biological Science Research Center, Southwest University, Chongqing, China, Key Laboratory for Germplasm Creation in Upper Reaches of the Yangtze River, Ministry of Agriculture and Rural Affairs, Chongqing, China
⨯
Lingyan Wang,

Roles Data curation

Affiliations Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Biological Science Research Center, Southwest University, Chongqing, China, Key Laboratory for Germplasm Creation in Upper Reaches of the Yangtze River, Ministry of Agriculture and Rural Affairs, Chongqing, China
⨯
Yang Cao,

Roles Conceptualization

Affiliations Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Biological Science Research Center, Southwest University, Chongqing, China, Key Laboratory for Germplasm Creation in Upper Reaches of the Yangtze River, Ministry of Agriculture and Rural Affairs, Chongqing, China
⨯
Qingyou Xia,

Roles Conceptualization

Affiliations Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Biological Science Research Center, Southwest University, Chongqing, China, Key Laboratory for Germplasm Creation in Upper Reaches of the Yangtze River, Ministry of Agriculture and Rural Affairs, Chongqing, China
⨯
Ping Zhao

Roles Conceptualization, Project administration

* E-mail: zhaop@swu.edu.cn

Affiliations Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Biological Science Research Center, Southwest University, Chongqing, China, Key Laboratory for Germplasm Creation in Upper Reaches of the Yangtze River, Ministry of Agriculture and Rural Affairs, Chongqing, China

https://orcid.org/0000-0002-2937-0457

⨯

Serpin-1a and serpin-6 regulate the Toll pathway immune homeostasis by synergistically inhibiting the Spätzle-processing enzyme CLIP2 in silkworm, Bombyx mori

Huawei Liu,
Jiahui Xu,
Luoling Wang,
Pengchao Guo,
Zhangchen Tang,
Xiaotong Sun,
Xin Tang,
Wei Wang,
Lingyan Wang,
Yang Cao

Published: October 18, 2023
https://doi.org/10.1371/journal.ppat.1011740

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