Structural and functional basis of low-affinity SAM/SAH-binding in the conserved MTase of the multi-segmented Alongshan virus distantly related to canonical unsegmented flaviviruses

• Hua Chen ,

  Contributed equally to this work with: Hua Chen, Sheng Lin

  Roles Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Emergency Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China, Department of Wound Repair and Rehabilitation Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Daping Hospital, Army Medical University, Chongqing, China

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• Sheng Lin ,

  Contributed equally to this work with: Hua Chen, Sheng Lin

  Roles Formal analysis, Investigation, Validation, Visualization, Writing – review & editing

  Affiliation Department of Emergency Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Fanli Yang,

  Roles Formal analysis, Funding acquisition, Validation, Visualization

  Affiliation Department of Emergency Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Zimin Chen,

  Roles Formal analysis, Investigation, Validation, Visualization

  Affiliation Department of Emergency Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Liyan Guo,

  Roles Formal analysis, Investigation, Validation

  Affiliation Department of Emergency Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Jing Yang,

  Roles Formal analysis, Investigation, Validation

  Affiliation Department of Emergency Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Xi Lin,

  Roles Investigation, Validation

  Affiliation Department of Emergency Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Lingling Wang,

  Roles Investigation

  Affiliation Department of Emergency Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Yanping Duan,

  Roles Investigation

  Affiliation Department of Emergency Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Ao Wen,

  Roles Investigation

  Affiliation Department of Emergency Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Xindan Zhang,

  Roles Investigation

  Affiliation Department of Emergency Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Yushan Dai,

  Roles Investigation

  Affiliation Department of Emergency Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Keqing Yin,

  Roles Investigation

  Affiliation Department of Emergency Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Xin Yuan,

  Roles Investigation

  Affiliation Department of Emergency Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Chongzhang Yu,

  Roles Investigation

  Affiliation Department of Emergency Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Yarong He,

  Roles Investigation, Resources

  Affiliation Department of Emergency Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Bin He,

  Roles Resources, Writing – review & editing

  Affiliation Department of Emergency Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Yu Cao,

  Roles Resources, Writing – review & editing

  Affiliations Department of Emergency Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China, Disaster Medicine Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Haohao Dong,

  Roles Methodology, Writing – review & editing

  Affiliation State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Jian Li,

  Roles Methodology, Writing – review & editing

  Affiliation School of Basic Medical Sciences, Chengdu University, Chengdu, Sichuan, China

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• Qi Zhao,

  Roles Methodology, Writing – review & editing

  Affiliation College of Food and Biological Engineering, Chengdu University, Chengdu, Sichuan, China

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• Quan Liu ,

  Roles Conceptualization, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: liuquan1973@hotmail.com (QL); lugw@scu.edu.cn (GL)

  Affiliation Center of Infectious diseases and Pathogen Biology, Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, The First Hospital of Jilin University, State Key Laboratory of Zoonotic Diseases, Changchun, Jilin, China

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•  [ ... ],
• Guangwen Lu

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: liuquan1973@hotmail.com (QL); lugw@scu.edu.cn (GL)

  Affiliation Department of Emergency Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China

  https://orcid.org/0000-0001-7568-592X

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