Functional and structural analyses reveal that a dual domain sialidase protects bacteria from complement killing through desialylation of complement factors

• Nicholas D. Clark ,

  Contributed equally to this work with: Nicholas D. Clark, Christopher Pham

  Roles Data curation, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Structural Biology, Jacobs School of Medicine and Biomedical Sciences, University of Buffalo, the State University of New York, Buffalo, New York, United States of America

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• Christopher Pham ,

  Contributed equally to this work with: Nicholas D. Clark, Christopher Pham

  Roles Data curation, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Philips Institute for Oral Health Research, Virginia Commonwealth University, Richmond, Virginia, United States of America

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• Kurni Kurniyati,

  Roles Data curation, Investigation, Methodology, Validation, Visualization

  Affiliation Philips Institute for Oral Health Research, Virginia Commonwealth University, Richmond, Virginia, United States of America

  ⨯
• Ching Wooen Sze,

  Roles Methodology

  Affiliation Philips Institute for Oral Health Research, Virginia Commonwealth University, Richmond, Virginia, United States of America

  ⨯
• Laurynn Coleman,

  Roles Methodology

  Affiliation Philips Institute for Oral Health Research, Virginia Commonwealth University, Richmond, Virginia, United States of America

  ⨯
• Qin Fu,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

  Affiliation Proteomics Facility, Institute of Biotechnology, Cornell University, Ithaca, New York, United States of America

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• Sheng Zhang,

  Roles Data curation, Formal analysis, Investigation, Methodology, Supervision, Writing – review & editing

  Affiliation Proteomics Facility, Institute of Biotechnology, Cornell University, Ithaca, New York, United States of America

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• Michael G. Malkowski ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: mgm22@buffalo.edu (MGM); cli5@vcu.edu (CL)

  Affiliation Department of Structural Biology, Jacobs School of Medicine and Biomedical Sciences, University of Buffalo, the State University of New York, Buffalo, New York, United States of America

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• Chunhao Li

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: mgm22@buffalo.edu (MGM); cli5@vcu.edu (CL)

  Affiliation Philips Institute for Oral Health Research, Virginia Commonwealth University, Richmond, Virginia, United States of America

  https://orcid.org/0000-0002-1872-4870

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