The development of resistance to an inhibitor of a cellular protein reveals a critical interaction between the enterovirus protein 2C and a small GTPase Arf1

• Ekaterina G. Viktorova,

  Roles Investigation, Methodology, Project administration, Supervision, Writing – review & editing

  Affiliation Department of Veterinary Medicine and Virginia-Maryland College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America

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• Samuel Gabaglio,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Department of Veterinary Medicine and Virginia-Maryland College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America

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• Seyedehmahsa Moghimi,

  Roles Investigation, Methodology, Writing – review & editing

  Current address: Early BioProcess Development, Vaccine Research and Development, Pfizer Inc., Pearl River, New York, United States of America

  Affiliation Department of Veterinary Medicine and Virginia-Maryland College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America

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• Anna Zimina,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Department of Veterinary Medicine and Virginia-Maryland College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America

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• Bridge G. Wynn,

  Roles Investigation, Methodology, Resources

  Affiliation Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham; Birmingham, Alabama, United States of America

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• Elizabeth Sztul ,

  Roles Funding acquisition, Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: esztul@uab.edu (ES); gbelov@umd.edu (GAB)

  Affiliation Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham; Birmingham, Alabama, United States of America

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• George A. Belov

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: esztul@uab.edu (ES); gbelov@umd.edu (GAB)

  Affiliation Department of Veterinary Medicine and Virginia-Maryland College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America

  https://orcid.org/0000-0002-0892-1731

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