Broad protective RBD heterotrimer vaccines neutralize SARS-CoV-2 including Omicron sub-variants XBB/BQ.1.1/BF.7

• Yanfang Zhang ,

  Contributed equally to this work with: Yanfang Zhang, Xinrui Kang, Sheng Liu, Pu Han, Wenwen Lei, Ke Xu

  Roles Formal analysis, Investigation, Visualization, Writing – review & editing

  Affiliation CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

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• Xinrui Kang ,

  Contributed equally to this work with: Yanfang Zhang, Xinrui Kang, Sheng Liu, Pu Han, Wenwen Lei, Ke Xu

  Roles Formal analysis, Investigation

  Affiliation Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China

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• Sheng Liu ,

  Contributed equally to this work with: Yanfang Zhang, Xinrui Kang, Sheng Liu, Pu Han, Wenwen Lei, Ke Xu

  Roles Investigation, Methodology

  Affiliation Cryo-EM Center, Southern University of Science and Technology, Shenzhen, China

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• Pu Han ,

  Contributed equally to this work with: Yanfang Zhang, Xinrui Kang, Sheng Liu, Pu Han, Wenwen Lei, Ke Xu

  Roles Investigation, Methodology

  Affiliation CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

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• Wenwen Lei ,

  Contributed equally to this work with: Yanfang Zhang, Xinrui Kang, Sheng Liu, Pu Han, Wenwen Lei, Ke Xu

  Roles Investigation

  Affiliation NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China

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• Ke Xu ,

  Contributed equally to this work with: Yanfang Zhang, Xinrui Kang, Sheng Liu, Pu Han, Wenwen Lei, Ke Xu

  Roles Investigation, Resources

  Affiliation NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China

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• Zepeng Xu,

  Roles Writing – original draft

  Affiliations CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China, Faculty of Health Sciences, University of Macau, Macau SAR, China

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• Zhengrong Gao,

  Roles Investigation

  Affiliations Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, Shenzhen Children’s Hospital, Shenzhen, China

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• Xuemei Zhou,

  Roles Investigation

  Affiliations CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China, School of Life Sciences, Hebei University, Baoding, China

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• Yaling An,

  Roles Investigation

  Affiliation Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China

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• Yuxuan Han,

  Roles Investigation

  Affiliation Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China

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• Kefang Liu,

  Roles Formal analysis

  Affiliation CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

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• Xin Zhao,

  Roles Formal analysis, Methodology, Resources

  Affiliation CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

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• Lianpan Dai,

  Roles Conceptualization, Formal analysis, Funding acquisition

  Affiliation CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

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• Peiyi Wang ,

  Roles Formal analysis, Project administration, Resources

  * E-mail: wangpy@sustech.edu.cn (PW); wugz@ivdc.chinacdc.cn (GW); jxqi@im.ac.cn (JQ); xukun@biols.ac.cn (KX); gaof@im.ac.cn (GFG)

  Affiliation Cryo-EM Center, Southern University of Science and Technology, Shenzhen, China

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• Guizhen Wu ,

  Roles Project administration, Resources

  * E-mail: wangpy@sustech.edu.cn (PW); wugz@ivdc.chinacdc.cn (GW); jxqi@im.ac.cn (JQ); xukun@biols.ac.cn (KX); gaof@im.ac.cn (GFG)

  Affiliation NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China

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• Jianxun Qi ,

  Roles Formal analysis, Funding acquisition, Project administration

  * E-mail: wangpy@sustech.edu.cn (PW); wugz@ivdc.chinacdc.cn (GW); jxqi@im.ac.cn (JQ); xukun@biols.ac.cn (KX); gaof@im.ac.cn (GFG)

  Affiliation CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

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• Kun Xu ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Writing – original draft, Writing – review & editing

  * E-mail: wangpy@sustech.edu.cn (PW); wugz@ivdc.chinacdc.cn (GW); jxqi@im.ac.cn (JQ); xukun@biols.ac.cn (KX); gaof@im.ac.cn (GFG)

  Affiliation Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, China

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•  [ ... ],
• George F. Gao

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – review & editing

  * E-mail: wangpy@sustech.edu.cn (PW); wugz@ivdc.chinacdc.cn (GW); jxqi@im.ac.cn (JQ); xukun@biols.ac.cn (KX); gaof@im.ac.cn (GFG)

  Affiliations CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China, Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China, Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, China

  https://orcid.org/0000-0002-3869-615X

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