Pharmacological inhibition of bromodomain and extra-terminal proteins induces an NRF-2-mediated antiviral state that is subverted by SARS-CoV-2 infection

• Baxolele Mhlekude,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Institute of Virology, Campus Charité Mitte, Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, Berlin Institute of Health at Charité–Universitätsmedizin Berlin, Berlin, Germany, Virology and Innate Immunity Research Group, Helmholtz Centre for Infection Research, Braunschweig, Germany, Institute of Genetics, Technische Universität Braunschweig, Braunschweig, Germany

  https://orcid.org/0000-0003-3696-2482

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• Dylan Postmus,

  Roles Data curation, Formal analysis, Methodology, Visualization, Writing – review & editing

  Affiliations Institute of Virology, Campus Charité Mitte, Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, Berlin Institute of Health at Charité–Universitätsmedizin Berlin, Berlin, Germany

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• Saskia Stenzel,

  Roles Formal analysis, Investigation, Visualization

  Affiliations Institute of Virology, Campus Charité Mitte, Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, Berlin Institute of Health at Charité–Universitätsmedizin Berlin, Berlin, Germany

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• January Weiner 3rd,

  Roles Data curation, Formal analysis, Visualization

  Affiliation Berlin Institute of Health at Charité–Universitätsmedizin Berlin, Berlin, Germany

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• Jenny Jansen,

  Roles Investigation

  Affiliations Institute of Virology, Campus Charité Mitte, Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, Berlin Institute of Health at Charité–Universitätsmedizin Berlin, Berlin, Germany

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• Francisco J. Zapatero-Belinchón,

  Roles Data curation, Formal analysis

  Affiliations Department of Biochemistry, University of Veterinary Medicine Hannover, Hannover, Germany, Institute of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover, Germany, Department of Clinical Microbiology, Virology & Wallenberg Centre for Molecular Medicine (WCMM), Umeå University, Umeå, Sweden

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• Ruth Olmer,

  Roles Funding acquisition, Methodology, Resources

  Affiliation Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery, REBIRTH—Center for Translational Regenerative Medicine, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover Medical School, Hannover, Germany

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• Anja Richter,

  Roles Investigation

  Affiliation Institute of Virology, Campus Charité Mitte, Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

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• Julian Heinze,

  Roles Investigation

  Affiliation Institute of Virology, Campus Charité Mitte, Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

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• Nicolas Heinemann,

  Roles Investigation

  Affiliation Institute of Virology, Campus Charité Mitte, Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

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• Barbara Mühlemann,

  Roles Investigation, Methodology, Validation

  Affiliation Institute of Virology, Campus Charité Mitte, Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

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• Simon Schroeder,

  Roles Investigation, Methodology

  Affiliation Institute of Virology, Campus Charité Mitte, Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

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• Terry C. Jones,

  Roles Funding acquisition, Methodology, Supervision, Validation

  Affiliations Institute of Virology, Campus Charité Mitte, Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, Centre for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge, United Kingdom

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• Marcel A. Müller,

  Roles Supervision

  Affiliation Institute of Virology, Campus Charité Mitte, Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

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• Christian Drosten,

  Roles Funding acquisition, Resources

  Affiliation Institute of Virology, Campus Charité Mitte, Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

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• Andreas Pich,

  Roles Data curation, Formal analysis, Investigation, Validation

  Affiliation Institute of Toxicology, Hannover Medical School, Core Facility Proteomics, Hannover, Germany

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• Volker Thiel,

  Roles Resources, Supervision

  Affiliations Institute of Virology and Immunology (IVI), University of Bern, Bern, Switzerland, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland

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• Ulrich Martin,

  Roles Funding acquisition, Resources, Supervision

  Affiliation Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery, REBIRTH—Center for Translational Regenerative Medicine, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover Medical School, Hannover, Germany

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• Daniela Niemeyer,

  Roles Methodology, Resources

  Affiliation Institute of Virology, Campus Charité Mitte, Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

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• Gisa Gerold,

  Roles Funding acquisition, Methodology, Supervision

  Affiliations Department of Biochemistry, University of Veterinary Medicine Hannover, Hannover, Germany, Institute of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover, Germany, Department of Clinical Microbiology, Virology & Wallenberg Centre for Molecular Medicine (WCMM), Umeå University, Umeå, Sweden

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• Dieter Beule,

  Roles Supervision

  Affiliation Berlin Institute of Health at Charité–Universitätsmedizin Berlin, Berlin, Germany

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•  [ ... ],
• Christine Goffinet

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: christine.goffinet@lstmed.ac.uk

  Affiliations Institute of Virology, Campus Charité Mitte, Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, Berlin Institute of Health at Charité–Universitätsmedizin Berlin, Berlin, Germany, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool United Kingdom

  https://orcid.org/0000-0002-3959-004X

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